Fujisaka Shiho, Watanabe Yoshiyuki, Toume Kazufumi, Morinaga Yoshitomo, Nawaz Allah, Kado Tomonobu, Nishimura Ayumi, Bilal Muhammad, Aslam Muhammad Rahil, Igarashi Yoshiko, Nakagawa Yoshimi, Tobe Kazuyuki
First Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 9300194 Japan.
Institute of Natural Medicine, University of Toyama, Toyama, 9300194 Japan.
Diabetol Int. 2024 Apr 6;15(3):495-506. doi: 10.1007/s13340-024-00713-w. eCollection 2024 Jul.
Disruption of the gut microbiota causes metabolic dysfunction, and intervention in the gut microbiota has the potential to improve host glucose metabolism. is an intestinal bacterium involved in anti-obesity and insulin resistance. Developing interventions to increase would be useful for new treatment strategies. In this study, we screened herbal drug extracts that promoted the growth of . . Among the 123 herbal drugs, five herbal drug extracts significantly increased . DNA levels compared with that in controls. In particular, Dioscoreae rhizoma extract increased the growth of . in the intestines of mice fed a high-fat diet and improved obesity. It significantly reduced body weight gain, improved glucose tolerance even when the administration was initiated after the induction of dietary obesity. These results suggest that herbal drug extracts, such as Dioscoreae rhizome, that increase . could be a new therapeutic strategy for metabolic syndrome.
The online version contains supplementary material available at 10.1007/s13340-024-00713-w.
肠道微生物群的破坏会导致代谢功能障碍，对肠道微生物群进行干预有可能改善宿主的葡萄糖代谢。[具体细菌名称]是一种参与抗肥胖和胰岛素抵抗的肠道细菌。开发增加[具体细菌名称]数量的干预措施将有助于制定新的治疗策略。在本研究中，我们筛选了促进[具体细菌名称]生长的草药提取物。在123种草药中，五种草药提取物与对照组相比显著增加了[具体细菌名称]的DNA水平。特别是，山药提取物增加了高脂饮食喂养小鼠肠道中[具体细菌名称]的生长，并改善了肥胖状况。它显著降低了体重增加，即使在饮食性肥胖诱导后开始给药，也改善了葡萄糖耐量。这些结果表明，增加[具体细菌名称]数量的草药提取物，如山药，可能是治疗代谢综合征的一种新的治疗策略。
在线版本包含可在10.1007/s13340-024-00713-w获取的补充材料。
