Filén Finn, Eriksen Jaran, Missailidis Catharina
överläkare, infektionssjukdomar och dermatovenereologi, Venhälsan, infektionskliniken, Södersjukhuset.
docent, specialistläkare, infektionssjukdomar och klinisk farmakologi, Venhälsan, infektionskliniken, Södersjukhuset.
Lakartidningen. 2024 Aug 2;121:24036.
STI prophylaxis using doxycycline is discussed internationally for persons at high risk of STIs (Doxy-PEP). Doxy-PEP would probably have limited effect on gonorrhoea due to resistance to tetracyclines. Doxy-PEP may reduce the incidence of chlamydia and syphilis, but would not reduce the number of complicated infections. Further studies are needed on the effects of intermittent antibiotic use on the microbiome or antibiotic resistance in general.
对于性传播感染（STI）高风险人群，国际上正在讨论使用多西环素进行STI预防（多西环素暴露后预防，Doxy-PEP）。由于对四环素耐药，多西环素暴露后预防对淋病可能效果有限。多西环素暴露后预防可能会降低衣原体感染和梅毒的发病率，但不会减少复杂感染的数量。关于间歇性使用抗生素对微生物群或总体抗生素耐药性的影响，还需要进一步研究。
