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Put a little doxy-PEP in your step: Using doxycycline to prevent chlamydia, syphilis, and gonorrhea infections.在你的行动中加入一点强力霉素暴露后预防：使用强力霉素预防衣原体、梅毒和淋病感染。
PLoS Pathog. 2024 Sep 30;20(9):e1012575. doi: 10.1371/journal.ppat.1012575. eCollection 2024 Sep.
2
[Do not overuse doxycycline as prophylaxis for uncomplicated sexually transmitted infections].[不要过度使用强力霉素预防非复杂性性传播感染]。
Lakartidningen. 2024 Aug 2;121:24036.
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Efficacy of Doxycycline as Preexposure and/or Postexposure Prophylaxis to Prevent Sexually Transmitted Diseases: A Systematic Review and Meta-Analysis.强力霉素作为暴露前和/或暴露后预防措施预防性传播疾病的疗效：一项系统评价和荟萃分析
Sex Transm Dis. 2025 Feb 1;52(2):65-72. doi: 10.1097/OLQ.0000000000002082. Epub 2024 Sep 24.
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Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design.多西环素预防和B型脑膜炎球菌疫苗预防法国细菌性性传播感染（ANRS 174 DOXYVAC）：一项采用2×2析因设计的多中心、开放标签随机试验。
Lancet Infect Dis. 2024 Oct;24(10):1093-1104. doi: 10.1016/S1473-3099(24)00236-6. Epub 2024 May 23.
5
Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention.多西环素暴露后预防以预防性传播感染
J Am Board Fam Med. 2025 Mar 21;37(6):1140-1142. doi: 10.3122/jabfm.2024.240056R0.
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Doxycycline prophylaxis for the prevention of sexually transmitted infections: A systematic review and meta-analysis of randomized controlled trials.多西环素预防性行为传播感染的效果：系统评价和随机对照试验的荟萃分析。
Int J Infect Dis. 2024 Oct;147:107186. doi: 10.1016/j.ijid.2024.107186. Epub 2024 Aug 8.
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Australian consensus statement on doxycycline post-exposure prophylaxis (doxy-PEP) for the prevention of syphilis, chlamydia and gonorrhoea among gay, bisexual and other men who have sex with men.澳大利亚关于多西环素暴露后预防（doxy-PEP）用于预防男同性恋、双性恋和其他与男性发生性关系的男性中的梅毒、衣原体和淋病的共识声明。
Med J Aust. 2024 Apr 15;220(7):381-386. doi: 10.5694/mja2.52258. Epub 2024 Mar 13.
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Doxycycline Postexposure Prophylaxis and Sexually Transmitted Infection Trends.多西环素暴露后预防与性传播感染趋势
JAMA Intern Med. 2025 Mar 1;185(3):266-272. doi: 10.1001/jamainternmed.2024.7178.
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Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.暴露后多西环素预防细菌性性传播感染。
N Engl J Med. 2023 Apr 6;388(14):1296-1306. doi: 10.1056/NEJMoa2211934.
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Doxycycline post-exposure prophylaxis for preventing bacterial sexually transmitted infections (STIs): Are clinical providers supportive?多西环素暴露后预防细菌性性传播感染：临床医疗服务提供者是否支持？
Int J STD AIDS. 2025 Mar;36(4):297-303. doi: 10.1177/09564624241309433. Epub 2024 Dec 24.

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1
Prevalence of genital and extragenital sexually transmitted infections among women of reproductive age with and without HIV in the Southern US: results from the study of treatment and reproductive outcomes.美国南部有和没有感染艾滋病毒的育龄妇女中生殖器和生殖器外性传播感染的患病率：治疗与生殖结局研究结果
Front Med (Lausanne). 2025 Mar 26;12:1537427. doi: 10.3389/fmed.2025.1537427. eCollection 2025.

本文引用的文献

1
Doxycycline postexposure prophylaxis may delay seroconversion in incident syphilis.暴露后使用多西环素进行预防可能会延迟初发性梅毒的血清学转换。
Sex Transm Infect. 2024 Aug 19;100(6):397. doi: 10.1136/sextrans-2024-056240.
2
Near-Universal Resistance to Macrolides of in North America.北美地区肺炎支原体对大环内酯类药物几乎普遍耐药。
N Engl J Med. 2024 Jun 13;390(22):2127-2128. doi: 10.1056/NEJMc2314441.
3
CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024.美国疾病预防控制中心 2024 年关于使用多西环素进行细菌性性传播感染预防的暴露后预防临床指南。
MMWR Recomm Rep. 2024 Jun 6;73(2):1-8. doi: 10.15585/mmwr.rr7302a1.
4
Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design.多西环素预防和B型脑膜炎球菌疫苗预防法国细菌性性传播感染（ANRS 174 DOXYVAC）：一项采用2×2析因设计的多中心、开放标签随机试验。
Lancet Infect Dis. 2024 Oct;24(10):1093-1104. doi: 10.1016/S1473-3099(24)00236-6. Epub 2024 May 23.
5
Equity of PrEP uptake by race, ethnicity, sex and region in the United States in the first decade of PrEP: a population-based analysis.在美国暴露前预防（PrEP）的首个十年中，按种族、族裔、性别和地区划分的PrEP使用公平性：一项基于人群的分析。
Lancet Reg Health Am. 2024 Apr 22;33:100738. doi: 10.1016/j.lana.2024.100738. eCollection 2024 May.
6
Doxycycline to Prevent Sexually Transmitted Infections in Women.强力霉素预防女性性传播感染
N Engl J Med. 2024 Apr 4;390(13):1248-1249. doi: 10.1056/NEJMc2401273.
7
Doxycycline Prophylaxis to Prevent Sexually Transmitted Infections in Women.强力霉素预防女性性传播感染
N Engl J Med. 2023 Dec 21;389(25):2331-2340. doi: 10.1056/NEJMoa2304007.
8
Safety of Longer-Term Doxycycline Use: A Systematic Review and Meta-Analysis With Implications for Bacterial Sexually Transmitted Infection Chemoprophylaxis.长期使用多西环素的安全性：系统评价和荟萃分析及其对细菌性性传播感染化学预防的意义。
Sex Transm Dis. 2023 Nov 1;50(11):701-712. doi: 10.1097/OLQ.0000000000001865. Epub 2023 Sep 4.
9
Potential impact of doxycycline post-exposure prophylaxis prescribing strategies on incidence of bacterial sexually transmitted infections.多西环素暴露后预防用药策略对细菌性性传播感染发病率的潜在影响。
Clin Infect Dis. 2023 Aug 18. doi: 10.1093/cid/ciad488.
10
Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.暴露后多西环素预防细菌性性传播感染。
N Engl J Med. 2023 Apr 6;388(14):1296-1306. doi: 10.1056/NEJMoa2211934.

Put a little doxy-PEP in your step: Using doxycycline to prevent chlamydia, syphilis, and gonorrhea infections.

作者信息

Meyerowitz Eric A, Liang Rina, Bishop Derek, Mullis Caroline E

机构信息

Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Bronx, New York, United States of America.

Albert Einstein College of Medicine, Bronx, New York, United States of America.

出版信息

PLoS Pathog. 2024 Sep 30;20(9):e1012575. doi: 10.1371/journal.ppat.1012575. eCollection 2024 Sep.

DOI:10.1371/journal.ppat.1012575
PMID:39348354
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11441668/
Abstract
摘要