Pocock R D, Witcombe J B, Andrews H S, Berry P J, Frank J D
Br J Urol. 1985 Dec;57(6):788-92. doi: 10.1111/j.1464-410x.1985.tb07055.x.
Twenty-eight patients undergoing routine antenatal screening by ultrasound were found to have a fetus with a major urological abnormality. In addition, two babies suspected of having an enlarged bladder were found post-natally to be normal. Seven of the 28 pregnancies were terminated before 26 weeks' gestation as a result of the ultrasound findings and all these fetuses had lethal renal abnormalities. Of the remaining 21 babies, four died of renal failure following delivery. Fifteen of the 17 babies who are alive and well had an ultrasound scan before 24 weeks' gestation. Only one of these scans revealed the abnormality. In the remaining patients the abnormality was first detected after 28 weeks. No patient had surgery in utero. Our data suggest that renal abnormalities detected prior to 24 weeks' gestation are associated with severe renal impairment. It appears that the role of antenatal drainage procedures may be of limited value.
通过超声进行常规产前筛查的28例患者被发现胎儿存在主要泌尿系统异常。此外，出生后发现2例疑似膀胱增大的婴儿正常。28例妊娠中有7例因超声检查结果在妊娠26周前终止妊娠，所有这些胎儿均有致命性肾脏异常。其余21例婴儿中，4例出生后死于肾衰竭。存活且健康的17例婴儿中有15例在妊娠24周前进行了超声扫描。这些扫描中只有1例显示出异常。其余患者的异常在28周后首次被发现。没有患者在子宫内接受手术。我们的数据表明，妊娠24周前检测到的肾脏异常与严重肾功能损害有关。产前引流手术的作用似乎有限。
