From the Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Ann Plast Surg. 2024 Aug 1;93(2S Suppl 1):S91-S97. doi: 10.1097/SAP.0000000000003933.
The skin is an intricate network of both neurons and immunocytes, where emerging evidence has indicated that the regulation of neural-inflammatory processes may play a crucial role in mediating wound healing. Disease associated abnormal immunological dysfunction and peripheral neuropathy are implicated in the pathogenesis of wound healing impairment. However, the mechanisms through which neural-inflammatory interactions modulate wound healing remain ambiguous. Understanding the underlying mechanisms may provide novel insights to develop therapeutic devices, which could manipulate neural-inflammatory crosstalk to aid wound healing. This review aims to comprehensively illustrate the neural-inflammatory interactions during different stages of the repair process. Numerous mediators including neuropeptides secreted by the sensory and autonomic nerve fibers and cytokines produced by immunocytes play an essential part during the distinct phases of wound healing.
皮肤是神经元和免疫细胞的复杂网络，新出现的证据表明，神经-炎症过程的调节可能在介导伤口愈合中起着关键作用。与疾病相关的免疫功能异常和周围神经病变与伤口愈合受损的发病机制有关。然而，神经-炎症相互作用调节伤口愈合的机制尚不清楚。了解这些机制可能为开发治疗设备提供新的思路，这些设备可以操纵神经-炎症的串扰来帮助伤口愈合。本综述旨在全面阐述修复过程不同阶段的神经-炎症相互作用。在伤口愈合的不同阶段，许多介质，包括感觉和自主神经纤维分泌的神经肽和免疫细胞产生的细胞因子，都起着重要作用。
