Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang, 421001, Hunan, China.
Probiotics Antimicrob Proteins. 2024 Dec;16(6):2229-2250. doi: 10.1007/s12602-024-10338-9. Epub 2024 Aug 5.
Lactiplantibacillus plantarum (previously known as Lactobacillus plantarum) is a lactic acid bacterium that exists in various niches. L. plantarum is a food-grade microorganism that is commonly considered a safe and beneficial microorganism. It is widely used in food fermentation, agricultural enhancement, and environmental protection. L. plantarum is also part of the normal flora that can regulate the intestinal microflora and promote intestinal health. Some strains of L. plantarum are powerful probiotics that induce and modulate the innate and adaptive immune responses. Due to its outstanding immunoregulatory capacities, an increasing number of studies have examined the use of probiotic L. plantarum strains as natural immune adjuvants or alternative live vaccine carriers. The present review summarizes the main immunomodulatory characteristics of L. plantarum and discusses the preliminary immunological effects of L. plantarum as a vaccine adjuvant and delivery carrier. Different methods for improving the immune capacities of recombinant vector vaccines are also discussed.
植物乳杆菌（以前称为植物乳杆菌）是一种存在于各种生境中的乳酸菌。植物乳杆菌是一种食品级微生物，通常被认为是一种安全有益的微生物。它被广泛应用于食品发酵、农业增产和环境保护。植物乳杆菌也是正常菌群的一部分，可以调节肠道微生物群落，促进肠道健康。一些植物乳杆菌菌株是强大的益生菌，可诱导和调节先天和适应性免疫反应。由于其出色的免疫调节能力，越来越多的研究探讨了使用益生菌植物乳杆菌菌株作为天然免疫佐剂或替代活疫苗载体。本综述总结了植物乳杆菌的主要免疫调节特性，并讨论了植物乳杆菌作为疫苗佐剂和递送载体的初步免疫学效应。还讨论了提高重组载体疫苗免疫能力的不同方法。
