一种新型甾体选择性雄激素受体调节剂（SARM）化合物 S42 的全面气相色谱电子电离高分辨率质谱研究。
A comprehensive gas chromatography electron ionization high resolution mass spectrometry study of a new steroidal selective androgen receptor modulator (SARM) compound S42.
机构信息
Department of Chemistry, Institute of Organic Chemistry, University of Cologne, Cologne, Germany.
Center for Preventive Doping Research/Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.
出版信息
J Mass Spectrom. 2024 Aug;59(8):e5077. doi: 10.1002/jms.5077.
The synthetic 20-keto-steroid S42 (1) demonstrated selective androgen receptor modulator (SARM) properties in preclinical studies and, consequently, received growing attention also in the context of sports drug testing programs. Fundamental understanding of the behavior of S42 (1) and of relevant derivatives in gas chromatography-electron ionization MS experiments at high resolution (GC-EI-HRMS) is indispensable to develop a reliable qualitative and quantitative doping control method for S42 (1) and its metabolites in body fluid matrices. We present important fundamental mechanistic data on the EI fragmentation behavior of S42 (1) and of silyl ether derivatives as well as of stable isotope-labelled reference material.
合成的 20-酮甾体 S42（1）在临床前研究中表现出选择性雄激素受体调节剂（SARM）的特性，因此也在运动药物检测计划中受到越来越多的关注。为了开发可靠的定性和定量兴奋剂控制方法，用于检测体液基质中的 S42（1）及其代谢物，必须深入了解 S42（1）和相关衍生物在高分辨气相色谱-电子电离质谱（GC-EI-HRMS）实验中的行为。我们提供了有关 S42（1）及其硅醚衍生物以及稳定同位素标记参考物质的 EI 断裂行为的重要基础机理数据。
Zotero 插件