Thevis Mario, Kuuranne Tiia, Geyer Hans
Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.
European Monitoring Center for Emerging Doping Agents, Cologne, Germany.
Drug Test Anal. 2025 Aug;17(8):1417-1442. doi: 10.1002/dta.3835. Epub 2024 Dec 28.
The 17th edition of the annual banned-substance review on analytical approaches in human sports drug testing is dedicated to literature published between October 2023 and September 2024. As in previous years, focus is put particularly on new or enhanced analytical options in human doping controls as well as investigations into the metabolism and elimination of compounds of interest, which represent central (while not exclusive) cornerstones of the global anti-doping mission. New information published within the past 12 months on established doping agents as well as new potentially relevant substances are reviewed and discussed in the context of the World Anti-Doping Agency's 2024 Prohibited List. Thereby, analytical challenges, especially with regard to the continuously growing number of target compounds and potentially relevant drug classes as well as the exigency (and consequences) of utmost analytical retrospectivity, are thematized and contextualized. Investigations especially into anabolic agents, peptide hormones, and strategies for the detection of gene doping were identified as core areas of anti-doping research in the reviewed period.
第17版年度人类运动药物检测分析方法禁用物质综述聚焦于2023年10月至2024年9月期间发表的文献。与往年一样，重点特别放在人类兴奋剂检测中的新分析方法或改进的分析方法，以及对相关化合物代谢和消除的研究上，这些是全球反兴奋剂任务的核心（但并非唯一）基石。过去12个月内发表的有关既定兴奋剂以及新的潜在相关物质的新信息，将在世界反兴奋剂机构《2024年禁用清单》的背景下进行审查和讨论。由此，分析挑战，尤其是随着目标化合物和潜在相关药物种类数量不断增加以及极高分析追溯性的紧迫性（和后果），得到了专题讨论和背景分析。对合成代谢药物、肽类激素的研究以及基因兴奋剂检测策略被确定为审查期间反兴奋剂研究的核心领域。
