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撤稿声明:碳酸酐酶4是临床预后不良的标志物,并通过核因子κB诱导的基质金属蛋白酶2表达促进鼻咽癌转移。

RETRACTION: Capn4 is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via Nuclear Factor-κB-Induced Matrix Metalloproteinase 2 Expression.

出版信息

Cancer Sci. 2024 Oct;115(10):3491. doi: 10.1111/cas.16305. Epub 2024 Aug 5.

Abstract

P.-C. Zheng, X. Chen, H.-W. Zhu, W. Zheng, L.-H. Mao, C. Lin, J.-N. Liu and M. Zheng, "Capn4 is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via Nuclear Factor-κB-Induced Matrix Metalloproteinase 2 Expression," Cancer Science 105, no. 6 (2014): 630-638, https://doi.org/10.1111/cas.12416. The above article, published online on 07 April 2014 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Masanori Hatakeyama; Japanese Cancer Association; and John Wiley & Sons Australia, Ltd. Following publication, concerns were raised by a third party regarding suspected overlap of elements within the western blot presented in Figure 3b and a figure published earlier in another paper elsewhere. Furthermore, image analysis uncovered several instances of overlap within the cell migration and cell invasion Transwell assay images presented in Figure 3c. The authors were unable to provide the original data and did not provide a satisfactory explanation for the overlaps. As a result, the article's conclusions can no longer be considered valid.

摘要

郑沛聪、陈晓、朱宏伟、郑伟、毛立华、林晨、刘建宁、郑明,“Capn4是临床不良预后的标志物,通过核因子κB诱导基质金属蛋白酶2表达促进鼻咽癌转移”,《癌症科学》105卷,第6期(2014年):630 - 638页,https://doi.org/10.1111/cas.12416 。上述文章于2014年4月7日在线发表于威利在线图书馆(wileyonlinelibrary.com),已根据期刊主编畠山正典、日本癌症协会以及约翰威立父子澳大利亚有限公司之间的协议撤回。文章发表后,第三方对图3b所示蛋白质印迹中的部分元素与另一篇较早发表于其他地方的论文中的一幅图疑似重叠表示关切。此外,图像分析发现图3c所示细胞迁移和细胞侵袭Transwell实验图像存在多处重叠。作者无法提供原始数据,也未对这些重叠给出令人满意的解释。因此,该文章的结论不再被认为有效。

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