单纯疱疹病毒 1 型是大学生生殖器疱疹的主要病因。

Herpes Simplex Type 1 as the Predominant Cause of Genital Herpes in College Students.

机构信息

From the University Health Services, University of Wisconsin Madison, Madison, WI.

Director of Epidemiology, Province of Tucuman, Virgen de La Merced 196, San Miguel de Tucuman, Tucuman, Argentina.

出版信息

Sex Transm Dis. 2024 Dec 1;51(12):784-787. doi: 10.1097/OLQ.0000000000002060. Epub 2024 Aug 8.

DOI:10.1097/OLQ.0000000000002060

PMID:39102507

Abstract

BACKGROUND

Genital herpes etiology has been shifting to include a greater proportion of herpes simplex virus type 1 (HSV-1) infection in the last few decades. A prior study published in 2003 found that 48.9% of infections in a college health population were HSV-1.

METHODS

We evaluated the number of positive HSV polymerase chain reaction test results obtained from anogenital sites from undergraduate and graduate students from 2013 to 2022 in a college health clinic setting and analyzed the number caused by HSV-1 and HSV type 2 and compared by sex. This was then compared with the prior study from 1993 to 2001.

RESULTS

We received 691 (of 2685 samples) positive polymerase chain reaction results for HSV of both types in the period analyzed. Overall, 600 (86.8%) of these were HSV-1, and 520 (75.2%) were in female patients. The prior study in 1993 to 2001 found that 48.9% (244 of 675) of all positive test results were HSV-1; we observed an increase in the percentage of positive HSV-1 over all positive test results of 1.8 ( χ2 = 16.548; P < 0.001).

CONCLUSIONS

Our study shows that 86.8% of the positive genital HSV test results from 2013 to 2022 were HSV-1. This shows that most positive HSV test results in this setting are now HSV-1, a substantial increase from the previous study in our clinic.

摘要

背景

在过去几十年中，生殖器疱疹的病因已逐渐转变为包括更多单纯疱疹病毒 1 型（HSV-1）感染。2003 年发表的一项先前研究发现，在大学生群体中，48.9%的感染者为 HSV-1。

方法

我们评估了 2013 年至 2022 年期间，在大学生健康诊所中，从本科生和研究生的肛门生殖器部位获得的 HSV 聚合酶链反应检测结果阳性的数量，并分析了由 HSV-1 和 HSV-2 引起的数量，按性别进行比较。然后将其与 1993 年至 2001 年的先前研究进行比较。

结果

我们在分析期间共收到 691 例（2685 例样本中）两种类型 HSV 的阳性聚合酶链反应结果。总体而言，这些结果中有 600 例（86.8%）为 HSV-1，其中 520 例（75.2%）为女性患者。1993 年至 2001 年的先前研究发现，所有阳性检测结果中，48.9%（244 例）为 HSV-1；我们观察到 HSV-1 阳性百分比相对于所有阳性检测结果增加了 1.8（ χ 2 = 16.548；P < 0.001）。