Iseki Masahiro, Mizuma Masamichi, Shimura Mitsuhiro, Kokumai Takashi, Sato Hideaki, Kusaka Akiko, Aoki Shuichi, Inoue Koetsu, Nakayama Shun, Douchi Daisuke, Miura Takayuki, Maeda Shimpei, Ishida Masaharu, Nakagawa Kei, Kamei Takashi, Unno Michiaki
From the Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Pancreas. 2025 Feb 1;54(2):e75-e81. doi: 10.1097/MPA.0000000000002396. Epub 2024 Aug 5.
The aim of this study was to investigate how preoperative chemotherapy affected the serum zinc concentrations in patients with pancreatic cancer (PC).
Two hundreds thirty-one patients with PC who underwent pancreatectomy at our department from 2013 to 2019 were enrolled in this study and measured for the serum zinc concentrations before pancreatectomy. Patient characteristics, course of treatment, and laboratory data were analyzed.
One hundred thirty-five patients underwent upfront pancreatectomy and 58 received preoperative gemcitabine + S1 (GEM + S1) and 29 received gemcitabine + nab-paclitaxel (GEM + nab-PTX). Comparing the serum zinc concentrations before and after preoperative treatment, it was found to decrease after treatment with statistical difference (79.3 μg/dL vs 68.7 μg/dL, P < 0.001). The result was consistent with the investigation for both the patients who received GEM + S1 and those who received GEM + nab-PTX ( P = 0.019, P < 0.001, respectively).
The preoperative chemotherapy consistently reduced the serum zinc concentrations in the PC patients, regardless of their regimen such as GEM + S1 and GEM + nab-PTX. Monitoring the serum zinc concentration and appropriate zinc supplementation may be essential for PC patients undergoing preoperative chemotherapy and pancreatectomy.
本研究旨在探讨术前化疗如何影响胰腺癌（PC）患者的血清锌浓度。
本研究纳入了2013年至2019年在我科接受胰腺切除术的231例PC患者，并在胰腺切除术前测量了他们的血清锌浓度。分析了患者特征、治疗过程和实验室数据。
135例患者接受了直接胰腺切除术，58例接受了术前吉西他滨+S1（GEM+S1）治疗，29例接受了吉西他滨+纳米白蛋白结合型紫杉醇（GEM+nab-PTX）治疗。比较术前治疗前后的血清锌浓度，发现治疗后血清锌浓度降低，差异有统计学意义（79.3μg/dL对68.7μg/dL，P<0.001）。接受GEM+S1治疗的患者和接受GEM+nab-PTX治疗的患者的调查结果一致（分别为P=0.019，P<0.001）。
无论采用何种化疗方案，如GEM+S1和GEM+nab-PTX，术前化疗均能持续降低PC患者的血清锌浓度。对于接受术前化疗和胰腺切除术的PC患者，监测血清锌浓度并适当补充锌可能至关重要。
