• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Copy Number Variations of Plasmodium vivax DBP1, EBP/DBP2, and RBP2b in Ethiopians Who Are Duffy Positive and Duffy Negative.红细胞血型蛋白 1（DBP1）、埃普斯坦蛋白/红细胞血型蛋白 2（EBP/DBP2）和富含半胱氨酸的红细胞蛋白 2b（RBP2b）的拷贝数变异在达菲阳性和达菲阴性的埃塞俄比亚人中的差异。
J Infect Dis. 2024 Oct 16;230(4):1004-1012. doi: 10.1093/infdis/jiae388.
2
Digital PCR reveals high PvDBP1 but not PvEBP/DBP2 and PvRBP2b copies in Plasmodium vivax from Duffy-negative Individuals in Central Africa.数字PCR显示，在来自中非达菲阴性个体的间日疟原虫中，PvDBP1拷贝数高，但PvEBP/DBP2和PvRBP2b拷贝数不高。
J Infect Dis. 2025 Jun 12. doi: 10.1093/infdis/jiaf322.
3
Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance.频繁扩展的埃塞俄比亚间日疟原虫 Duffy 结合蛋白及其流行病学意义。
PLoS Negl Trop Dis. 2019 Sep 11;13(9):e0007222. doi: 10.1371/journal.pntd.0007222. eCollection 2019 Sep.
4
Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans.间日疟原虫达菲结合蛋白1在达菲阴性非洲人入侵中的作用。
Proc Natl Acad Sci U S A. 2016 May 31;113(22):6271-6. doi: 10.1073/pnas.1606113113. Epub 2016 May 17.
5
Spatial distribution of Plasmodium vivax Duffy Binding Protein copy number variation and Duffy genotype, and their association with parasitemia in Ethiopia.埃塞俄比亚间日疟原虫达菲结合蛋白拷贝数变异和达菲基因型的空间分布及其与寄生虫血症的关联。
PLoS Negl Trop Dis. 2025 Feb 13;19(2):e0012837. doi: 10.1371/journal.pntd.0012837. eCollection 2025 Feb.
6
Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes.对间日疟原虫分离株的全基因组测序揭示了红细胞结合基因中频繁的序列和结构多态性。
PLoS Negl Trop Dis. 2020 Oct 12;14(10):e0008234. doi: 10.1371/journal.pntd.0008234. eCollection 2020 Oct.
7
Complement receptor 1 is the human erythrocyte receptor for erythrocyte binding protein.补体受体 1 是人类红细胞的红细胞结合蛋白受体。
Proc Natl Acad Sci U S A. 2024 Jan 30;121(5):e2316304121. doi: 10.1073/pnas.2316304121. Epub 2024 Jan 23.
8
Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications.间日疟原虫达菲结合蛋白基因重复的独立起源与全球分布
PLoS Negl Trop Dis. 2016 Oct 31;10(10):e0005091. doi: 10.1371/journal.pntd.0005091. eCollection 2016 Oct.
9
Exploring the genetic diversity pattern of PvEBP/DBP2: A promising candidate for an effective Plasmodium vivax vaccine.探索 PvEBP/DBP2 的遗传多样性模式：一种有希望的有效间日疟原虫疫苗候选物。
Acta Trop. 2024 Jul;255:107231. doi: 10.1016/j.actatropica.2024.107231. Epub 2024 Apr 27.
10
Comparative transcriptomics reveal differential gene expression among Plasmodium vivax geographical isolates and implications on erythrocyte invasion mechanisms.比较转录组学揭示了间日疟原虫地理株之间的差异基因表达及其对红细胞入侵机制的影响。
PLoS Negl Trop Dis. 2024 Jan 29;18(1):e0011926. doi: 10.1371/journal.pntd.0011926. eCollection 2024 Jan.

引用本文的文献

1
The pattern of gene amplification of members of the Plasmodium vivax erythrocyte binding-like proteins family across the Amazon rainforest.间日疟原虫红细胞结合样蛋白家族成员在亚马逊雨林中的基因扩增模式。
Res Sq. 2025 Jul 10:rs.3.rs-7048749. doi: 10.21203/rs.3.rs-7048749/v1.

本文引用的文献

1
Detection of Duffy blood group genotypes and submicroscopic Plasmodium infections using molecular diagnostic assays in febrile malaria patients.采用分子诊断检测技术在发热性疟疾患者中检测达菲血型基因型和亚微观疟原虫感染。
Malar J. 2024 Jun 20;23(1):194. doi: 10.1186/s12936-024-04875-5.
2
Comparative transcriptomics reveal differential gene expression among Plasmodium vivax geographical isolates and implications on erythrocyte invasion mechanisms.比较转录组学揭示了间日疟原虫地理株之间的差异基因表达及其对红细胞入侵机制的影响。
PLoS Negl Trop Dis. 2024 Jan 29;18(1):e0011926. doi: 10.1371/journal.pntd.0011926. eCollection 2024 Jan.
3
Complement receptor 1 is the human erythrocyte receptor for erythrocyte binding protein.补体受体 1 是人类红细胞的红细胞结合蛋白受体。
Proc Natl Acad Sci U S A. 2024 Jan 30;121(5):e2316304121. doi: 10.1073/pnas.2316304121. Epub 2024 Jan 23.
4
Unveiling P. vivax invasion pathways in Duffy-negative individuals.揭示无 Duffy 血型个体中间日疟原虫的入侵途径。
Cell Host Microbe. 2023 Dec 13;31(12):2080-2092.e5. doi: 10.1016/j.chom.2023.11.007. Epub 2023 Dec 5.
5
Relationship between Duffy Genotype/Phenotype and Prevalence of Infection: A Systematic Review.达菲基因型/表型与感染患病率之间的关系：一项系统评价。
Trop Med Infect Dis. 2023 Sep 30;8(10):463. doi: 10.3390/tropicalmed8100463.
6
Mechanistic within-host models of the asexual Plasmodium falciparum infection: a review and analytical assessment.无性疟原虫感染的宿主内机制模型：综述与分析评估。
Malar J. 2021 Jul 10;20(1):309. doi: 10.1186/s12936-021-03813-z.
7
Home Sweet Home: -Infected Reticulocytes-The Younger the Better?甜蜜家园：感染的网织红细胞——越年轻越好？
Front Cell Infect Microbiol. 2021 May 13;11:675156. doi: 10.3389/fcimb.2021.675156. eCollection 2021.
8
Hidden Biomass of Intact Malaria Parasites in the Human Spleen.人类脾脏中完整疟原虫的隐藏生物量。
N Engl J Med. 2021 May 27;384(21):2067-2069. doi: 10.1056/NEJMc2023884.
9
Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa.非洲无 Duffy 阴性个体感染间日疟原虫的流行病学和遗传变异对比。
Int J Infect Dis. 2021 Jul;108:63-71. doi: 10.1016/j.ijid.2021.05.009. Epub 2021 May 12.
10
Plasmodium vivax From Duffy-Negative and Duffy-Positive Individuals Share Similar Gene Pools in East Africa.东非无反应性 Duffy 阴性和 Duffy 阳性个体间的间日疟原虫具有相似的基因库。
J Infect Dis. 2021 Oct 28;224(8):1422-1431. doi: 10.1093/infdis/jiab063.

红细胞血型蛋白 1（DBP1）、埃普斯坦蛋白/红细胞血型蛋白 2（EBP/DBP2）和富含半胱氨酸的红细胞蛋白 2b（RBP2b）的拷贝数变异在达菲阳性和达菲阴性的埃塞俄比亚人中的差异。

Copy Number Variations of Plasmodium vivax DBP1, EBP/DBP2, and RBP2b in Ethiopians Who Are Duffy Positive and Duffy Negative.

机构信息

Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania.

Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina.

出版信息

J Infect Dis. 2024 Oct 16;230(4):1004-1012. doi: 10.1093/infdis/jiae388.

DOI:10.1093/infdis/jiae388
PMID:39102894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11481331/
Abstract

Recent evidence challenges the belief that individuals who are Duffy-negative are resistant to Plasmodium vivax due to lacking the Duffy antigen receptor for chemokines. Erythrocyte-binding protein (EBP/DBP2) has shown moderate binding to Duffy-negative erythrocytes in vitro. Reticulocyte-binding protein 2b (RBP2b) interactions with transferrin receptor 1 suggest involvement in Duffy-negative infections. Gene copy number variations in PvDBP1, PvEBP/DBP2, and PvRBP2b were investigated in Duffy-positive and Duffy-negative P vivax infections from Ethiopia. Among Duffy-positive samples, 34% displayed PvDBP1 duplications (Cambodian type). In Duffy-negative infections, 30% showed duplications, mostly Cambodian type. For PvEBP/DBP2 and PvRBP2b, Duffy-positive samples exhibited higher duplication rates (1-8 copies for PvEBP/DBP2, 46%; 1-5 copies for PvRBP2b, 43%) as compared with Duffy-negative samples (20.8% and 26%, respectively). The range of copy number variations was lower in Duffy-negative infections. Demographic and clinical factors associated with gene multiplications in both Duffy types were explored, enhancing understanding of P vivax evolution in Africans who are Duffy negative.

摘要

最近的证据挑战了这样一种观点，即缺乏趋化因子的 Duffy 抗原受体的 Duffy 阴性个体对间日疟原虫具有抗性。红细胞结合蛋白 (EBP/DBP2) 在体外对 Duffy 阴性红细胞表现出中等结合能力。网织红细胞结合蛋白 2b (RBP2b) 与转铁蛋白受体 1 的相互作用表明其参与了 Duffy 阴性感染。在来自埃塞俄比亚的 Duffy 阳性和 Duffy 阴性间日疟原虫感染中，研究了 PvDBP1、PvEBP/DBP2 和 PvRBP2b 的基因拷贝数变异。在 Duffy 阳性样本中，34%显示 PvDBP1 重复（柬埔寨型）。在 Duffy 阴性感染中，30%显示重复，主要是柬埔寨型。对于 PvEBP/DBP2 和 PvRBP2b，Duffy 阳性样本的重复率更高（PvEBP/DBP2 为 1-8 个拷贝，46%；PvRBP2b 为 1-5 个拷贝，43%），而 Duffy 阴性样本分别为 20.8%和 26%。Duffy 阴性感染中的拷贝数变异范围较低。探索了与两种 Duffy 类型基因倍增相关的人口统计学和临床因素，增强了对非洲 Duffy 阴性人群间日疟原虫进化的理解。