Picón-Jaimes Yelson Alejandro, Lozada-Martinez Ivan David, Orozco-Chinome Javier Esteban, Molina-Franky Jessica, Acevedo-Lopez Domenica, Acevedo-Lopez Nicole, Bolaño-Romero Maria Paz, Visconti-Lopez Fabriccio J, Bonilla-Aldana D Katterine, Rodriguez-Morales Alfonso J
Fac Ciències Salut Blanquerna, University Ramon Llul, 08022 Barcelona, Spain.
Epidemiology Program, Department of Graduate Studies in Health Sciences, Universidad Autónoma de Bucaramanga, Bucaramanga 44005, Colombia.
Trop Med Infect Dis. 2023 Sep 30;8(10):463. doi: 10.3390/tropicalmed8100463.
The Duffy protein, a transmembrane molecule, functions as a receptor for various chemokines and facilitates attachment between the reticulocyte and the Duffy antigen-binding protein. Duffy expression correlates with the Duffy receptor gene for the chemokine, located on chromosome 1, and exhibits geographical variability worldwide. Traditionally, researchers have described the Duffy negative genotype as a protective factor against infection. However, recent studies suggest that this microorganism's evolution could potentially diminish this protective effect. Nevertheless, there is currently insufficient global data to demonstrate this phenomenon. This study aimed to evaluate the relationship between the Duffy genotype/phenotype and the prevalence of infection. The protocol for the systematic review was registered in PROSPERO as CRD42022353427 and involved reviewing published studies from 2012 to 2022. The Medline/PubMed, Web of Science, Scopus, and SciELO databases were consulted. Assessments of study quality were conducted using the STROBE and GRADE tools. A total of 34 studies were included, with Africa accounting for the majority of recorded studies. The results varied significantly regarding the relationship between the Duffy genotype/phenotype and invasion. Some studies predominantly featured the negative Duffy genotype yet reported no malaria cases. Other studies identified minor percentages of infections. Conversely, certain studies observed a higher prevalence (99%) of Duffy-negative individuals infected with In conclusion, this systematic review found that the homozygous Duffy genotype positive for the A allele (FY*A/*A) is associated with a higher incidence of infection. Furthermore, the negative Duffy genotype does not confer protection against vivax malaria.
达菲蛋白是一种跨膜分子，作为多种趋化因子的受体，促进网织红细胞与达菲抗原结合蛋白之间的附着。达菲的表达与位于1号染色体上的趋化因子达菲受体基因相关，并在全球范围内呈现出地理变异性。传统上，研究人员将达菲阴性基因型描述为预防感染的保护因素。然而，最近的研究表明，这种微生物的进化可能会削弱这种保护作用。尽管如此，目前全球范围内尚无足够的数据来证明这一现象。本研究旨在评估达菲基因型/表型与感染患病率之间的关系。该系统评价方案已在国际前瞻性系统评价注册库（PROSPERO）中注册，注册号为CRD42022353427，涉及回顾2012年至2022年发表的研究。检索了医学文献数据库（Medline/PubMed）、科学引文索引（Web of Science）、Scopus和科学电子图书馆在线（SciELO）数据库。使用加强流行病学观察性研究报告标准（STROBE）和推荐分级的评估、制定与评价（GRADE）工具对研究质量进行评估。共纳入34项研究，其中大部分记录研究来自非洲。关于达菲基因型/表型与感染之间的关系，结果差异很大。一些研究主要以达菲阴性基因型为主，但未报告疟疾病例。其他研究发现感染率较低。相反，某些研究观察到达菲阴性个体感染的患病率较高（99%）。总之，这项系统评价发现，A等位基因纯合阳性的达菲基因型（FY*A/*A）与感染发生率较高有关。此外，达菲阴性基因型并不能预防间日疟。
