Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.
Department of Neurology, Odense University Hospital, Odense, Denmark.
Sci Rep. 2024 Aug 5;14(1):18068. doi: 10.1038/s41598-024-68915-5.
Physical activity can worsen migraine, leading to reduced activity levels in adults with chronic migraine. This study investigated the change in average steps per day, as a surrogate marker of physical activity, in adults with chronic migraine successfully treated with monoclonal antibodies against calcitonin gene-related peptide or its receptor. Data were obtained from adults with chronic migraine, who were classified as responders to preventive treatment with monoclonal antibodies. The primary endpoint was the difference in a mean number of steps per day between the 3 months prior to treatment initiation and the first 3 months after treatment initiation. The secondary endpoint was the correlation between the change in steps per day and the change in monthly migraine days. Twenty-two (20 females) participants with a median age of 48.5 years were enrolled. The median number of steps per day increased from 4421 at baseline to 5241 after treatment (P = 0.039). We found a positive correlation between the increase in steps per day and the treatment response (P = 0.013). In conclusion, an increase in physical activity, based on steps per day, positively correlated with treatment response to monoclonal antibodies. Automatically registered daily step count data might be used to monitor physical activity as a response to preventive treatment in adults with chronic migraine.
身体活动可能会加重偏头痛，导致慢性偏头痛成年人的活动水平降低。这项研究调查了接受降钙素基因相关肽单克隆抗体或其受体治疗的慢性偏头痛成年人的平均每日步数变化，这是身体活动的替代标志物。数据来自被分类为对预防性单克隆抗体治疗有反应的慢性偏头痛成年人。主要终点是治疗开始前 3 个月和治疗开始后 3 个月之间平均每日步数的差异。次要终点是每日步数变化与每月偏头痛天数变化之间的相关性。22 名（20 名女性）中位年龄为 48.5 岁的参与者入组。每日步数中位数从基线时的 4421 步增加到治疗后的 5241 步（P = 0.039）。我们发现每日步数的增加与治疗反应之间存在正相关（P = 0.013）。总之，基于每日步数的身体活动增加与单克隆抗体治疗反应呈正相关。自动登记的日常步数数据可能可用于监测慢性偏头痛成年人预防治疗的身体活动反应。
