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富血小板血浆与可注射富血小板纤维蛋白治疗大鼠睾丸扭转/复位损伤的疗效比较。

Comparison of the therapeutic effect of platelet-rich plasma and injectable platelet-rich fibrin on testicular torsion/detorsion injury in rats.

机构信息

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.

Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.

出版信息

Sci Rep. 2024 Aug 5;14(1):18045. doi: 10.1038/s41598-024-67704-4.

DOI:10.1038/s41598-024-67704-4
PMID:39103420
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300838/
Abstract

Testicular torsion is a common disorder in males and results in blockage of testicular circulation with subsequent damage of testicular germ cells. The current work aimed to compare the therapeutic effect of platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) on torsion/detorsion (T/D) injury in rats. Forty mature male Wister rats were arranged into 4 groups; (1) Control, (2) T/D, (3) T/D + PRP, and (4) T/D+ i-PRF. The right testis was twisting 1080° clockwise for 3 h in groups 2, 3 and 4, then 10 μl of PRP or i-PRF was injected intra-testicular 3 h after detorsion in groups 3 and 4, respectively. After 30 days postoperatively, the semen quality and hormonal assay were improved in PRP and i-PRF-treated groups with superiority of i-PRF (P < 0.001). High significance of Catalase, Glutathione Peroxidase (GPx), Superoxide Dismutase, Interleukin-1β (IL-1β), Caspase-3 and Tumor necrosis factor-α (TNF-α) was reported in treated rats with PRP and i-PRF (P < 0.001) with superiority to i-PRF-treated rats (P < 0.001). Testicular histoarchitectures were improved in PRP and i-PRF-treated rats with superiority of i-PRF-treated rats. It was concluded that PRP and i-PRF have regenerative efficacy on testicular damage after induced T/D injury with a superior efficacy of i-PRF.

摘要

睾丸扭转是男性常见的疾病，导致睾丸循环阻塞，随后睾丸生殖细胞受损。本研究旨在比较富血小板血浆（PRP）和可注射富血小板纤维蛋白（i-PRF）治疗大鼠扭转/复位（T/D）损伤的疗效。将 40 只成熟雄性 Wistar 大鼠分为 4 组；（1）对照组，（2）T/D 组，（3）T/D+PRP 组和（4）T/D+i-PRF 组。在第 2、3 和 4 组中，将右侧睾丸顺时针扭转 1080°3 小时，然后在第 3 和第 4 组中分别在复位后 3 小时内向睾丸内注射 10 μl 的 PRP 或 i-PRF。术后 30 天，PRP 和 i-PRF 治疗组的精液质量和激素测定均得到改善，i-PRF 组的效果更优（P<0.001）。PRP 和 i-PRF 治疗组的 Catalase、Glutathione Peroxidase (GPx)、Superoxide Dismutase、Interleukin-1β (IL-1β)、Caspase-3 和 Tumor necrosis factor-α (TNF-α) 水平显著升高（P<0.001），i-PRF 治疗组的效果更优（P<0.001）。PRP 和 i-PRF 治疗组的睾丸组织学结构得到改善，i-PRF 治疗组的效果更优。结论：PRP 和 i-PRF 对诱导的 T/D 损伤后睾丸损伤具有再生作用，i-PRF 的疗效更优。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/7b72a0c54d68/41598_2024_67704_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/eccae185200c/41598_2024_67704_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/eb0c1dffbb1d/41598_2024_67704_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/b093c7a9f703/41598_2024_67704_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/ef12b4108604/41598_2024_67704_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/cfb0cfd70e34/41598_2024_67704_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/22f6965ebceb/41598_2024_67704_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/94b9c35db5e7/41598_2024_67704_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/7b72a0c54d68/41598_2024_67704_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/eccae185200c/41598_2024_67704_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/eb0c1dffbb1d/41598_2024_67704_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/b093c7a9f703/41598_2024_67704_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/ef12b4108604/41598_2024_67704_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/cfb0cfd70e34/41598_2024_67704_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/22f6965ebceb/41598_2024_67704_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/94b9c35db5e7/41598_2024_67704_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc60/11300838/7b72a0c54d68/41598_2024_67704_Fig8_HTML.jpg

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