棉酚与低钾血症

Gossypol and hypokalaemia.

作者信息

Wang C, Yeung R T

出版信息

Contraception. 1985 Sep;32(3):237-52. doi: 10.1016/0010-7824(85)90047-2.

Abstract

One major side effect of administration of gossypol as a male fertility regulating agent is the occurrence of hypokalaemic paralysis. We have reviewed the common causes of hypokalaemia in clinical practice and previous studies of gossypol-induced hypokalaemia in animals and man. The available evidences suggest that gossypol induced renal leakage of potassium. The most likely mechanism is a direct toxic effect of gossypol on the renal tubules.

摘要

作为一种男性生育调节药物，棉酚给药的一个主要副作用是低钾性麻痹的发生。我们回顾了临床实践中低钾血症的常见原因以及以往关于棉酚诱导动物和人类低钾血症的研究。现有证据表明，棉酚导致钾从肾脏漏出。最可能的机制是棉酚对肾小管的直接毒性作用。