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正中隔的解剖及其与白质的连接。

Topographical anatomy of the septum verum and its white matter connections.

机构信息

Department of Neurosurgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Department of Anatomy, Semmelweis University, Budapest, Hungary.

出版信息

Sci Rep. 2024 Aug 5;14(1):18064. doi: 10.1038/s41598-024-68464-x.

DOI:10.1038/s41598-024-68464-x
PMID:39103521
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300447/
Abstract

The human septum verum represents a small but clinically important region of the brain. Based on the results of animal experiments, the stimulation of its medial part was recently proposed with various indications like epilepsy or cognitive impairment after traumatic brain injury. The aim of our study was to present the anatomical relationships of the human septum verum using fiber dissection and histological analysis to support its research and provide essential information for future deep brain stimulation therapies. 16 human cadaveric brains were dissected according to Klingler's method. To validate our macroscopical findings, 12 samples obtained from the dissected brains and 2 additional specimens from unfrozen brains were prepared for histological examinations. We identified the following white matter connections of the septum verum: (1) the precommissural fibers of the fornix; (2) the inferior fascicle of the septum pellucidum; (3) the cingulum; (4) the medial olfactory stria; (5) the ventral amygdalofugal pathway; (6) the stria medullaris of the thalamus and (7) the stria terminalis. Moreover, we could distinguish a less-known fiber bundle connecting the postcommissural column of the fornix to the stria medullaris of the thalamus and the anterior thalamic nuclei. In this study we present valuable anatomical information about this region to promote safe and effective deep brain stimulation therapies in the future.

摘要

人类真隔核是大脑中一个虽小但具有重要临床意义的区域。基于动物实验的结果，最近有人提出刺激其内侧部分可用于多种适应症，如癫痫或创伤性脑损伤后的认知障碍。我们的研究目的是使用纤维解剖和组织学分析来呈现人类真隔核的解剖关系，以支持其研究并为未来的深部脑刺激治疗提供必要信息。根据 Klingler 的方法对 16 个人体尸体大脑进行了解剖。为了验证我们的宏观发现，我们对从解剖大脑中获得的 12 个样本和另外 2 个来自未冷冻大脑的样本进行了组织学检查。我们确定了真隔核的以下白质连接：（1）穹窿的前连合纤维；（2）透明隔的下纤维束；（3）扣带；（4）内侧嗅纹；（5）腹侧杏仁核传出通路；（6）丘脑髓纹和（7）终纹。此外，我们还可以区分出一条不太知名的纤维束，将穹窿的后连合柱与丘脑髓纹和前丘脑核连接起来。在这项研究中，我们提供了关于该区域的有价值的解剖信息，以促进未来安全有效的深部脑刺激治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/3197bb88dbf8/41598_2024_68464_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/24f6a9e932d5/41598_2024_68464_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/25ecbb0f6787/41598_2024_68464_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/711be12f8b59/41598_2024_68464_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/3b0c60273cf2/41598_2024_68464_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/ef11be619f78/41598_2024_68464_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/257e510bbd5c/41598_2024_68464_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/4a58dd5febc7/41598_2024_68464_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/2a66936651ba/41598_2024_68464_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/3197bb88dbf8/41598_2024_68464_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/24f6a9e932d5/41598_2024_68464_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/25ecbb0f6787/41598_2024_68464_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/711be12f8b59/41598_2024_68464_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/3b0c60273cf2/41598_2024_68464_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/ef11be619f78/41598_2024_68464_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/257e510bbd5c/41598_2024_68464_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/4a58dd5febc7/41598_2024_68464_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/2a66936651ba/41598_2024_68464_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f062/11300447/3197bb88dbf8/41598_2024_68464_Fig9_HTML.jpg

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本文引用的文献

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Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review.原发于透明隔区域的中枢神经系统淋巴瘤：两例病例报告并文献复习。
Medicine (Baltimore). 2023 Nov 17;102(46):e35954. doi: 10.1097/MD.0000000000035954.
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Deep Brain Stimulation for Depression.深部脑刺激治疗抑郁症。
Neurotherapeutics. 2022 Jul;19(4):1229-1245. doi: 10.1007/s13311-022-01270-3. Epub 2022 Jul 11.
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A stepwise laboratory manual for the dissection and illustration of limbic and paralimbic structures: lessons learned from the Klingler's technique.
逐步实验室手册，用于解剖和描绘边缘和旁边缘结构：从 Klingler 技术中获得的经验教训。
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The Role of the Medial Septum-Associated Networks in Controlling Locomotion and Motivation to Move.中隔核相关网络在控制运动和运动动机中的作用。
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