Department of Critical Care Medicine, The First Medical Center, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Medical School of Chinese PLA, Beijing, 100853, China.
J Transl Med. 2024 Aug 5;22(1):722. doi: 10.1186/s12967-024-05486-z.
Aging is a multifaceted process that affects all organ systems. With the increasing trend of population aging, aging-related diseases have resulted in significant medical challenges and socioeconomic burdens. Mesenchymal stromal cells (MSCs), due to their antioxidative stress, immunoregulatory, and tissue repair capabilities, hold promise as a potential anti-aging intervention.
In this study, we transplanted MSCs into naturally aged rats at 24 months, and subsequently examined levels of aging-related factors such as β-galactosidase, superoxide dismutase, p16, p21 and malondialdehyde in multiple organs. Additionally, we assessed various aging-related phenotypes in these aged rats, including immune senescence, lipid deposition, myocardial fibrosis, and tissue damage. We also conducted a 16 S ribosomal ribonucleic acid (rRNA) analysis to study the composition of gut microbiota.
The results indicated that MSCs significantly reduced the levels of aging-associated and oxidative stress-related factors in multiple organs such as the heart, liver, and lungs of naturally aging rats. Furthermore, they mitigated chronic tissue damage and inflammation caused by aging, reduced levels of liver lipid deposition and myocardial fibrosis, alleviated aging-associated immunodeficiency and immune cell apoptosis, and positively influenced the gut microbiota composition towards a more youthful state. This research underscores the diverse anti-aging effects of MSCs, including oxidative stress reduction, tissue repair, metabolic regulation, and improvement of immune functions, shedding light on the underlying anti-aging mechanisms associated with MSCs.
The study confirms that MSCs hold great promise as a potential anti-aging approach, offering the possibility of extending lifespan and improving the quality of life in the elderly population.
衰老是一个多方面的过程，影响所有器官系统。随着人口老龄化趋势的增加，与衰老相关的疾病给医疗带来了巨大的挑战和社会经济负担。间充质基质细胞（MSCs）由于其抗氧化应激、免疫调节和组织修复能力，有望成为一种潜在的抗衰老干预手段。
在这项研究中，我们将 MSCs 移植到 24 个月大的自然衰老大鼠体内，随后检测了β-半乳糖苷酶、超氧化物歧化酶、p16、p21 和丙二醛等与衰老相关的因子在多个器官中的水平。此外，我们评估了这些老年大鼠的各种与衰老相关的表型，包括免疫衰老、脂质沉积、心肌纤维化和组织损伤。我们还进行了 16S 核糖体核糖核酸（rRNA）分析，以研究肠道微生物群的组成。
结果表明，MSCs 显著降低了自然衰老大鼠心脏、肝脏和肺部等多个器官中与衰老相关和氧化应激相关的因子水平。此外，它们减轻了衰老引起的慢性组织损伤和炎症，降低了肝脏脂质沉积和心肌纤维化的水平，缓解了与衰老相关的免疫缺陷和免疫细胞凋亡，并积极影响了肠道微生物群的组成，使其向更年轻的状态发展。这项研究强调了 MSCs 的多种抗衰老作用，包括降低氧化应激、组织修复、代谢调节和改善免疫功能，揭示了与 MSCs 相关的潜在抗衰老机制。
该研究证实 MSCs 作为一种潜在的抗衰老方法具有很大的潜力，为延长老年人群的寿命和提高生活质量提供了可能。
