饮食镁摄入量与类风湿关节炎患者全因死亡率：来自 NHANES 数据库的证据。

Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database.

机构信息

Queen Mary School, Nanchang University, Nanchang, 330036, Jiangxi Province, China.

West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.

出版信息

J Health Popul Nutr. 2024 Aug 5;43(1):112. doi: 10.1186/s41043-024-00597-1.

DOI:10.1186/s41043-024-00597-1

PMID:39103944

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11302089/

Abstract

BACKGROUND

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with all-cause mortality increasing globally. Dietary magnesium (Mg), an anti-inflammatory nutrient, has been proven to be associated with the all-cause mortality. The association of dietary Mg intake and all-cause mortality in RA patients remains unknown. The aim of this study was to assess the association between dietary Mg intake and all-cause mortality in RA patients.

METHODS

RA patients were extracted from the NHANES 1999-2018, and followed for survival through December 31, 2019. Dietary Mg intake data were obtained from 24-h dietary recall interview. The association between dietary Mg intake and RA patients' all-cause mortality was explored based on weighted univariate and multivariate Cox proportional hazard models and described as absolute risk difference (ARD), hazard ratios (HRs) and 95% confidence intervals (CIs). This association was further explored in subgroup analyses based on different age, gender and body mass index (BMI).

RESULTS

Totally 2,952 patients were included. Until 31 December 2019, a total of 825 deaths were documented. RA patients with higher dietary Mg intake had a 11.12% reduction of all-cause mortality (ARD=-11.12%; HR = 0.74, 95%CI: 0.56-0.99) in the fully adjusted model, especially in female (HR = 0.68, 95%CI: 0.47-0.98), aged < 65 years (HR = 0.59, 95%CI: 0.37-0.94) and BMI ≤ 30 kg/m (HR = 0.62, 95%CI: 0.42-0.91).

CONCLUSION

RA patients who consumed adequate dietary Mg from diet as well as supplements may had a lower risk of all-cause mortality.

摘要

背景

类风湿关节炎（RA）是一种慢性炎症性关节疾病，全球全因死亡率不断上升。镁（Mg）作为一种抗炎营养素，已被证明与全因死亡率有关。饮食中镁的摄入量与 RA 患者全因死亡率之间的关系尚不清楚。本研究旨在评估 RA 患者饮食中镁摄入量与全因死亡率之间的关系。

方法

从 NHANES 1999-2018 中提取 RA 患者，并通过 2019 年 12 月 31 日的生存随访。通过 24 小时膳食回顾访谈获得饮食镁摄入量数据。基于加权单变量和多变量 Cox 比例风险模型探索饮食镁摄入量与 RA 患者全因死亡率之间的关系，并以绝对风险差异（ARD）、风险比（HR）和 95%置信区间（CI）表示。根据不同的年龄、性别和体重指数（BMI）进一步在亚组分析中探讨这种关系。

结果

共纳入 2952 名患者。截至 2019 年 12 月 31 日，共记录到 825 例死亡。在完全调整后的模型中，饮食中镁摄入量较高的 RA 患者全因死亡率降低了 11.12%（ARD=-11.12%；HR=0.74，95%CI：0.56-0.99），尤其是女性（HR=0.68，95%CI：0.47-0.98）、年龄<65 岁（HR=0.59，95%CI：0.37-0.94）和 BMI≤30 kg/m（HR=0.62，95%CI：0.42-0.91）。