Queen Mary School, Nanchang University, Nanchang, 330036, Jiangxi Province, China.
West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.
J Health Popul Nutr. 2024 Aug 5;43(1):112. doi: 10.1186/s41043-024-00597-1.
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with all-cause mortality increasing globally. Dietary magnesium (Mg), an anti-inflammatory nutrient, has been proven to be associated with the all-cause mortality. The association of dietary Mg intake and all-cause mortality in RA patients remains unknown. The aim of this study was to assess the association between dietary Mg intake and all-cause mortality in RA patients. METHODS: RA patients were extracted from the NHANES 1999-2018, and followed for survival through December 31, 2019. Dietary Mg intake data were obtained from 24-h dietary recall interview. The association between dietary Mg intake and RA patients' all-cause mortality was explored based on weighted univariate and multivariate Cox proportional hazard models and described as absolute risk difference (ARD), hazard ratios (HRs) and 95% confidence intervals (CIs). This association was further explored in subgroup analyses based on different age, gender and body mass index (BMI). RESULTS: Totally 2,952 patients were included. Until 31 December 2019, a total of 825 deaths were documented. RA patients with higher dietary Mg intake had a 11.12% reduction of all-cause mortality (ARD=-11.12%; HR = 0.74, 95%CI: 0.56-0.99) in the fully adjusted model, especially in female (HR = 0.68, 95%CI: 0.47-0.98), aged < 65 years (HR = 0.59, 95%CI: 0.37-0.94) and BMI ≤ 30 kg/m (HR = 0.62, 95%CI: 0.42-0.91). CONCLUSION: RA patients who consumed adequate dietary Mg from diet as well as supplements may had a lower risk of all-cause mortality.
背景：类风湿关节炎（RA）是一种慢性炎症性关节疾病，全球全因死亡率不断上升。镁（Mg）作为一种抗炎营养素，已被证明与全因死亡率有关。饮食中镁的摄入量与 RA 患者全因死亡率之间的关系尚不清楚。本研究旨在评估 RA 患者饮食中镁摄入量与全因死亡率之间的关系。
方法：从 NHANES 1999-2018 中提取 RA 患者，并通过 2019 年 12 月 31 日的生存随访。通过 24 小时膳食回顾访谈获得饮食镁摄入量数据。基于加权单变量和多变量 Cox 比例风险模型探索饮食镁摄入量与 RA 患者全因死亡率之间的关系，并以绝对风险差异（ARD）、风险比（HR）和 95%置信区间（CI）表示。根据不同的年龄、性别和体重指数（BMI）进一步在亚组分析中探讨这种关系。
结果：共纳入 2952 名患者。截至 2019 年 12 月 31 日，共记录到 825 例死亡。在完全调整后的模型中，饮食中镁摄入量较高的 RA 患者全因死亡率降低了 11.12%（ARD=-11.12%；HR=0.74，95%CI：0.56-0.99），尤其是女性（HR=0.68，95%CI：0.47-0.98）、年龄<65 岁（HR=0.59，95%CI：0.37-0.94）和 BMI≤30 kg/m（HR=0.62，95%CI：0.42-0.91）。
结论：从饮食和补充剂中摄入足够镁的 RA 患者全因死亡率可能较低。
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