Department of Rheumatology Immunology and Endocrinology, Honghui Hospital Affiliated of Xi'an Jiaotong University, No.76 Nanguo Road, Beilin District, Xi'an, Shaanxi Province, 710061, China.
Department of Geriatric, Xi'an Qinhuang Hospital, Xi'an, Shaanxi Province, 710061, China.
J Health Popul Nutr. 2024 Jul 5;43(1):103. doi: 10.1186/s41043-024-00572-w.
Rheumatoid arthritis (RA) is a systemic autoimmune disease, and depression is a most frequent comorbid condition associated with RA. Studies have shown that inflammation plays a vital role in the pathophysiology of depression and RA. Mediterranean diet (MED) has been proved to be a healthy anti-inflammatory dietary pattern. This study aims to explore the association between the adherence to Mediterranean diet (aMED) and depression in RA patients.
In this study, RA patients aged ≥ 20 years old were extracted from the National Health and Nutrition Examination Survey (NAHNES) database. Dietary intake information was obtained from 24-h dietary recall interview. Covariates included sociodemographic information, lifestyles, laboratory parameters, and the history of diseases and medications were included. The weighted univariable and multivariable logistic regression models were used to assess the association between aMED and depression. Subgroup analysis was conducted to further explore the association between MED components and depression.
Totally 1,148 patients were included, of whom 290 (25.26%) had depression. After adjusted all covariates, high aMED was associated with the lower odds of depression in RA patients (OR = 0.53, 95%CI: 0.29-0.97). Among MED components, higher consumption of vegetables (OR = 0.54, 95%CI: 0.34-0.84) and cereals (OR = 0.63, 95%CI: 0.39-0.99) contributed more to decrease the odds of depression.
Greater aMED may have potential benefits for improving mental health in RA patients. Future large-scale cohort studies are needed to explore the association between aMED and depression in RA patients.
类风湿关节炎（RA）是一种系统性自身免疫性疾病，抑郁症是与 RA 相关的最常见合并症之一。研究表明，炎症在抑郁症和 RA 的病理生理学中起着至关重要的作用。地中海饮食（MED）已被证明是一种健康的抗炎饮食模式。本研究旨在探讨 RA 患者地中海饮食（aMED）依从性与抑郁症之间的关系。
本研究从全国健康和营养调查（NAHNES）数据库中提取了年龄≥20 岁的 RA 患者。饮食摄入信息来自 24 小时膳食回顾访谈。协变量包括社会人口统计学信息、生活方式、实验室参数以及疾病和药物治疗史。采用加权单变量和多变量逻辑回归模型评估 aMED 与抑郁症之间的关系。进行亚组分析以进一步探讨 MED 成分与抑郁症之间的关系。
共纳入 1148 例患者，其中 290 例（25.26%）患有抑郁症。调整所有协变量后，高 aMED 与 RA 患者抑郁症发生的几率较低相关（OR=0.53，95%CI：0.29-0.97）。在 MED 成分中，较高的蔬菜（OR=0.54，95%CI：0.34-0.84）和谷物（OR=0.63，95%CI：0.39-0.99）摄入量与降低抑郁症发生几率的关系更为显著。
更大程度地遵循 aMED 可能对改善 RA 患者的心理健康有益。未来需要进行大规模的队列研究来探讨 RA 患者 aMED 与抑郁症之间的关系。
