Kazmi S M, Baquer N Z
Enzyme. 1985;34(2):57-63. doi: 10.1159/000469363.
Studies with brain alanine aminotransferase showed higher activity of the enzyme in the soluble fraction of cerebellum. Among the tissues, the liver soluble fraction was the richest source of the enzyme. Alloxan-induced diabetes caused both regional and time-dependent variations in the activity of brain alanine aminotransferase. Significant among these changes were the decrease in both soluble and particulate enzyme from cerebral hemispheres and an increase in the soluble enzyme activity from cerebellum at early stages of diabetes. Brain stem did not show any marked change in enzyme activity. Liver and heart enzyme, however, increased significantly after 1-2 weeks of diabetes. Insulin treatment to diabetic animals caused an 'over-shoot' in soluble alanine aminotransferase activity, particularly in cerebellum and liver.
对脑丙氨酸转氨酶的研究表明，该酶在小脑的可溶部分活性较高。在所有组织中，肝脏可溶部分是该酶最丰富的来源。四氧嘧啶诱导的糖尿病导致脑丙氨酸转氨酶活性出现区域和时间依赖性变化。这些变化中显著的是，在糖尿病早期，大脑半球的可溶和颗粒性酶均减少，而小脑的可溶酶活性增加。脑干的酶活性未显示出任何明显变化。然而，糖尿病1-2周后，肝脏和心脏的酶活性显著增加。对糖尿病动物进行胰岛素治疗会导致可溶丙氨酸转氨酶活性“过冲”，尤其是在小脑和肝脏中。
