Kazmi S M, Mayanil C S, Baquer N Z
Enzyme. 1985;34(2):98-106. doi: 10.1159/000469369.
Regionally selective and time-dependent variations were observed in the activity of brain aspartate aminotransferase at early phases of diabetes. Malate dehydrogenase activity showed an opposite pattern of changes in soluble and particulate fractions of cerebral hemispheres and brain stem, with cerebellum showing consistent increase in the activity. The activity of both the enzymes increased significantly in liver, in contrast to heart where malate dehydrogenase activity decreased in particulate fraction. Insulin treatment to diabetic animals restored the enzymes to near control levels at early stages of diabetes, except in liver. The results indicate that malate-aspartate shuttle is probably stimulated under diabetic conditions to enable glycolysis to continue and ATP levels to be restored partially, particularly in cerebellum and liver.
在糖尿病早期阶段，观察到脑天冬氨酸转氨酶活性存在区域选择性和时间依赖性变化。苹果酸脱氢酶活性在大脑半球和脑干的可溶性和颗粒性部分呈现相反的变化模式，而小脑的该酶活性持续增加。与心脏相反，肝脏中这两种酶的活性均显著增加，心脏中颗粒性部分的苹果酸脱氢酶活性降低。对糖尿病动物进行胰岛素治疗，在糖尿病早期阶段可使酶恢复到接近对照水平，但肝脏除外。结果表明，在糖尿病条件下，苹果酸 - 天冬氨酸穿梭可能受到刺激，以使糖酵解能够继续并部分恢复ATP水平，特别是在小脑和肝脏中。
