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Cytokine profile of anti-spike CD4T cells predicts humoral and CD8T cell responses after anti-SARS-CoV-2 mRNA vaccination.

作者信息

Benhamouda Nadine, Besbes Anissa, Bauer Rebecca, Mabrouk Nesrine, Gadouas Gauthier, Desaint Corinne, Chevrier Lucie, Lefebvre Maeva, Radenne Anne, Roelens Marie, Parfait Béatrice, Weiskopf Daniela, Sette Alessandro, Gruel Nadège, Courbebaisse Marie, Appay Victor, Paul Stephane, Gorochov Guy, Ropers Jacques, Lebbah Said, Lelievre Jean-Daniel, Johannes Ludger, Ulmer Jonathan, Lebeaux David, Friedlander Gerard, De Lamballerie Xavier, Ravel Patrice, Kieny Marie Paule, Batteux Fréderic, Durier Christine, Launay Odile, Tartour Eric

机构信息

Department of Immunology, Hôpital Européen Georges-Pompidou, Hôpital Necker Department of Immunology, Paris, France.

Université Paris Cité, INSERM U970, PARCC, Department of Immunology, Hôpital Européen Georges-Pompidou, Hôpital Necker Department of Immunology, Paris, France.

出版信息

iScience. 2024 Jul 2;27(8):110441. doi: 10.1016/j.isci.2024.110441. eCollection 2024 Aug 16.

DOI:10.1016/j.isci.2024.110441
PMID:39104410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11298648/
Abstract

Coordinating immune responses - humoral and cellular - is vital for protection against severe Covid-19. Our study evaluates a multicytokine CD4T cell signature's predictive for post-vaccinal serological and CD8T cell responses. A cytokine signature composed of four cytokines (IL-2, TNF-α, IP10, IL-9) excluding IFN-γ, and generated through machine learning, effectively predicted the CD8T cell response following mRNA-1273 or BNT162b2 vaccine administration. Its applicability extends to murine vaccination models, encompassing diverse immunization routes (such as intranasal) and vaccine platforms (including adjuvanted proteins). Notably, we found correlation between CD4T lymphocyte-produced IL-21 and the humoral response. Consequently, we propose a test that offers a rapid overview of integrated immune responses. This approach holds particular relevance for scenarios involving immunocompromised patients because they often have low cell counts (lymphopenia) or pandemics. This study also underscores the pivotal role of CD4T cells during a vaccine response and highlights their value in vaccine immunomonitoring.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/771b1f6a49f3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/751de8e05b89/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/b1e6cfd49b52/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/453b6417ad32/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/b51e1b7784ba/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/6296cc17bde4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/c390d9fa210d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/85e2ec2948e8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/771b1f6a49f3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/751de8e05b89/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/b1e6cfd49b52/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/453b6417ad32/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/b51e1b7784ba/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/6296cc17bde4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/c390d9fa210d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/85e2ec2948e8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e738/11298648/771b1f6a49f3/gr7.jpg

相似文献

[1]
Cytokine profile of anti-spike CD4T cells predicts humoral and CD8T cell responses after anti-SARS-CoV-2 mRNA vaccination.

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[2]
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[10]
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引用本文的文献

[1]
The immunological impact of revaccination in a hybrid-immune world.

Front Immunol. 2025-6-9

[2]
Evaluation of humoral and cellular immune responses in healthcare workers with varying levels of SARS-CoV-2 exposure: effects of CoronaVac vaccination followed by heterologous booster.

Front Immunol. 2025-5-8

[3]
Development of a personalized digital biomarker of vaccine-associated reactogenicity using wearable sensors and digital twin technology.

Commun Med (Lond). 2025-4-13

[4]
Impact of QazVac vaccination on clinical manifestations and immune responses in post-COVID syndrome: a cross-sectional study.

Front Med (Lausanne). 2025-3-26

本文引用的文献

[1]
The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role.

Oxf Open Immunol. 2021-2-23

[2]
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease.

Nat Med. 2023-7

[3]
T Cell Responses to SARS-CoV-2.

Annu Rev Immunol. 2023-4-26

[4]
Impact of SARS-CoV-2 exposure history on the T cell and IgG response.

Cell Rep Med. 2023-1-17

[5]
Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years.

Sci Rep. 2022-11-27

[6]
Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination.

Sci Immunol. 2022-12-23

[7]
Role of B cells as antigen presenting cells.

Front Immunol. 2022

[8]
Plasma CD27, a Surrogate of the Intratumoral CD27-CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma.

Clin Cancer Res. 2022-11-14

[9]
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques.

Sci Immunol. 2022-11-18

[10]
Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic.

Cell Host Microbe. 2022-9-14

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