Roa Pia-Allison, Bostwick Jolene R, Patel Paresh D, Quigley Joanna, Thompson Amy N, Ward Kristen M
Pharmacy Resident, Michigan Medicine, Ann Arbor, Michigan.
Assistant Dean for Cocurriculum and Professional Development and Clinical Professor, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan.
Ment Health Clin. 2024 Aug 2;14(4):236-241. doi: 10.9740/mhc.2024.08.236. eCollection 2024 Aug.
Treatment-emergent sexual dysfunction (TESD) is a commonly reported side effect of antidepressant medications in clinical trials. Limited literature exists exploring the role of routine use of the Arizona Sexual Experience Scale (ASEX) in identification of TESD in clinical practice. Therefore, we completed a retrospective study with the primary goal of capturing the rates of sexual dysfunction associated with antidepressant use among adult patients at an outpatient encounter with a psychiatric clinical pharmacist between June 2020 and March 2022.
Rates of identification of sexual dysfunction were compared pre-ASEX survey (June 2020 to June 2021) to post-ASEX survey (July 2021 to March 2022).
There was a significant increase in the identification of sexual dysfunction following implementation of the ASEX scale (10% in the pre-ASEX group versus 59% meeting sexual dysfunction criteria with the ASEX scale). Approximately 70% of patients in the post-ASEX group shared they would not have reported symptoms unless directly asked.
In conclusion, a validated survey (ASEX) in an ambulatory psychiatry clinic improves identification of sexual dysfunction associated with antidepressants. Use of interdisciplinary care teams in the setting of medication follow-up can assist with identifying tolerability concerns between visits with patients' prescribing clinicians.
治疗引发的性功能障碍(TESD)是临床试验中抗抑郁药物常见的副作用。关于在临床实践中常规使用亚利桑那性体验量表(ASEX)在识别TESD方面的作用,现有文献有限。因此,我们完成了一项回顾性研究,主要目的是了解2020年6月至2022年3月期间,在门诊与精神科临床药剂师接触的成年患者中,与使用抗抑郁药物相关的性功能障碍发生率。
将ASEX量表调查前(2020年6月至2021年6月)和调查后(2021年7月至2022年3月)性功能障碍的识别率进行比较。
实施ASEX量表后,性功能障碍的识别率显著提高(ASEX量表调查前为10%,而符合性功能障碍标准的在ASEX量表调查后为59%)。ASEX量表调查后约70%的患者表示,除非被直接询问,他们不会报告症状。
总之,在门诊精神病诊所使用经过验证的调查(ASEX)可提高对与抗抑郁药相关的性功能障碍的识别。在药物随访中使用跨学科护理团队有助于在患者与开处方的临床医生就诊期间识别耐受性问题。