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分次二氧化碳激光对人黑素细胞及白癜风小鼠模型黑素生成的影响

The Effect of Fractional Carbon Dioxide Laser on Melanogenesis in Human Melanocytes and Vitiligo Mouse Models.

作者信息

Tang Hui, Ding Xiaoxia, Huang Youming, Xu Danfeng, Fan Yibin

机构信息

Graduate School of Clinical Medicine, Bengbu Medical College, Bengbu, 233030, People's Republic of China.

Center for Plastic & Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, 310014, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2024 Aug 1;17:1729-1737. doi: 10.2147/CCID.S445131. eCollection 2024.

DOI:10.2147/CCID.S445131
PMID:39104773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11299858/
Abstract

INTRODUCTION

Vitiligo is an acquired skin pigmentation disorder, the cause of which is poorly understood. Researchers in this field are dedicated to exploring novel treatments for achieving re-pigmentation.

METHODS

Mice were randomly selected and divided into control, model, and model+laser groups. Evaluate the impact of different levels of carbon dioxide laser irradiation on tyrosinase activity, melanocyte viability, and melanin content.

RESULTS

In this study, it was found that the cell viability and melanin content were significantly enhanced in human melanocytes after treatment with different energy densities of fractional carbon dioxide laser. In addition, laser-treated vitiligo mouse models showed mild pathological changes.

DISCUSSION

Therefore, we believe that fractional carbon dioxide laser may be a potential adjunctive modality for treating vitiligo.

摘要

引言

白癜风是一种后天性皮肤色素沉着紊乱疾病，其病因尚不清楚。该领域的研究人员致力于探索实现色素再生的新疗法。

方法

随机选取小鼠并分为对照组、模型组和模型+激光组。评估不同水平的二氧化碳激光照射对酪氨酸酶活性、黑素细胞活力和黑色素含量的影响。

结果

在本研究中，发现用不同能量密度的分次二氧化碳激光处理后人黑素细胞的细胞活力和黑色素含量显著增强。此外，激光治疗的白癜风小鼠模型显示出轻度病理变化。

讨论

因此，我们认为分次二氧化碳激光可能是治疗白癜风的一种潜在辅助方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/07662aa014c7/CCID-17-1729-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/c8baad1dd5d3/CCID-17-1729-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/c4c8a917391d/CCID-17-1729-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/71e1d0db0f7d/CCID-17-1729-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/07662aa014c7/CCID-17-1729-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/c8baad1dd5d3/CCID-17-1729-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/c4c8a917391d/CCID-17-1729-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/71e1d0db0f7d/CCID-17-1729-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94d8/11299858/07662aa014c7/CCID-17-1729-g0004.jpg

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J Cosmet Dermatol. 2022 Nov;21(11):5636-5641. doi: 10.1111/jocd.15116. Epub 2022 Jun 7.
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