Triana Primary Health Care Center, Servicio Canario de la Salud, Las Palmas de Gran Canaria, Spain.
Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Front Endocrinol (Lausanne). 2024 Jul 22;15:1412261. doi: 10.3389/fendo.2024.1412261. eCollection 2024.
Obesity is a pathological state that involves the dysregulation of different metabolic pathways and adipose tissue cells, constituting a risk factor for the development of other diseases. Bariatric surgery is the most effective treatment. The study of the behavior of pollutants in situations of extreme weight loss can provide biomonitoring information and tools to manage diseases of environmental etiology.
To determine the prevalence of serum persistent and non-persistent pollutants in obese patients subjected to bariatric surgery and analyze the impact of sociodemographic variables on these changes.
GC-MS/MS and UHPLC-MS/MS were utilized to determine the detection rates and concentrations of 353 compounds, including persistent organic pollutants (POPs), pesticides, pharmaceuticals, and rodenticide, in serum samples of 59 obese patients before and after undergoing bariatric surgery.
Detection rates of p,p'-DDE, HCB, β-HCH, naphthalene, phenanthrene and PCB congeners 138, 153 and 180 significantly increased due to surgery-induced weight loss. Serum levels of p,p'-DDE, PCB-138, PCB-153 and PCB-180 also increased after surgery. Correlations between naphthalene levels, weight loss, variation of total lipids and time after surgery were found. Additionally, correlations were observed between concentrations of PCB-138 and weight loss, and between phenanthrene levels and reduction of total lipids. No statistically significant differences were observed for other groups of contaminants, pharmaceuticals and other chemicals included in the quantification methods.
Increment of POPs was observed after bariatric surgery. Serum concentrations of POPs after surgery were influenced by adiposity-related variables. Although biomonitoring studies show a decreasing tendency of exposure, rapid weight loss leads to an increase of circulating POPs. Further research on the interplay between adipose tissue, POPs and peripheral organs is required.
肥胖是一种病理状态，涉及不同代谢途径和脂肪细胞的失调，是其他疾病发展的一个风险因素。减重手术是最有效的治疗方法。研究污染物在体重急剧下降情况下的行为可以提供生物监测信息和工具，以管理环境病因的疾病。
确定接受减重手术的肥胖患者血清中持久性和非持久性污染物的流行率，并分析社会人口统计学变量对这些变化的影响。
利用 GC-MS/MS 和 UHPLC-MS/MS 测定了 59 名肥胖患者术前和术后血清中 353 种化合物的检出率和浓度，包括持久性有机污染物（POPs）、农药、药物和杀鼠剂。
由于手术引起的体重减轻，p,p'-DDE、HCB、β-HCH、萘、菲和 PCB 同系物 138、153 和 180 的检出率显著增加。术后血清中 p,p'-DDE、PCB-138、PCB-153 和 PCB-180 的水平也有所增加。还发现了萘水平与体重减轻、总脂质变化和术后时间之间的相关性。此外，还观察到了 PCB-138 浓度与体重减轻之间、以及菲水平与总脂质减少之间的相关性。对于包括在定量方法中的其他污染物、药物和其他化学物质组，没有观察到统计学上的显著差异。
减重手术后观察到 POPs 的增加。手术后血清中 POPs 的浓度受肥胖相关变量的影响。尽管生物监测研究显示暴露有下降趋势，但快速减肥会导致循环中 POPs 的增加。需要进一步研究脂肪组织、POPs 和外周器官之间的相互作用。
