Ramos-Luzardo Álvaro, Valerón Pilar Fernández, Díaz-González Beatriz Vanessa, Zumbado Manuel, Simbaña-Rivera Katherine, Bautista-Castaño Inmaculada, Ruiz-Suárez Norberto, Hernández-García Elisabeth, Cornejo-Torre Judith, Luzardo Octavio P, Serra-Majem Lluis, Henríquez-Hernández Luis Alberto
Department of Biochemistry and Molecular Biology, Physiology, Genetics, and Immunology, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Toxicology Unit, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Toxics. 2025 Feb 23;13(3):152. doi: 10.3390/toxics13030152.
Adipose tissue, in addition to serving as energy storage, can store lipophilic substances, some of which may pose a health risk if massively mobilized during rapid weight loss. This study aimed to biomonitor inorganic elements in obese patients undergoing bariatric surgery and analyze the role of sociodemographic factors. ICP-MS was employed to quantify 55 elements, including elements identified from the ATSDR's Substance Priority List and rare-earth elements, in serum samples of 58 obese patients before and after bariatric surgery. A total of 39 out of 55 elements were detected, either before or after surgery, in at least one patient. Serum concentrations of gold, copper, mercury, platinum, and selenium significantly decreased after surgery. Serum concentrations of iron and zinc were significantly lower before surgery. Age, sex, diabetes status, arterial hypertension, and family history of obesity were demographic factors associated with the concentration of elements. Correlation analyses showed significant associations between elements and total lipid concentration or body mass index. Our findings indicate a complex interplay between inorganic elements and body fat and provide relevant information regarding the biomonitoring of these chemical elements in a specific and understudied population.
脂肪组织除了作为能量储存外，还能储存亲脂性物质，如果在快速减肥过程中大量动员这些物质，其中一些可能会对健康构成风险。本研究旨在对接受减肥手术的肥胖患者进行无机元素生物监测，并分析社会人口统计学因素的作用。采用电感耦合等离子体质谱法（ICP-MS）对58例肥胖患者减肥手术前后血清样本中的55种元素进行定量分析，包括从美国疾病控制与预防中心有害物质优先清单中确定的元素和稀土元素。55种元素中共有39种在至少一名患者的手术前或手术后被检测到。手术后血清中金、铜、汞、铂和硒的浓度显著降低。手术前血清中铁和锌的浓度显著较低。年龄、性别、糖尿病状况、动脉高血压和肥胖家族史是与元素浓度相关的人口统计学因素。相关性分析表明元素与总脂质浓度或体重指数之间存在显著关联。我们的研究结果表明无机元素与体脂之间存在复杂的相互作用，并为在特定且研究较少的人群中对这些化学元素进行生物监测提供了相关信息。
