Cataneo-Piña Daniela Josefina, Castorena-Maldonado Armando, González-Islas Dulce, Galicia-Amor Susana, Orea-Tejeda Arturo, Pelaez-Hernández Viridiana, Gutiérrez-Álvarez Alma Delia, Rojas-Serrano Jorge, Ortiz-Reyes Eduardo, Mendoza-Méndez Aline, Mendoza-Escamilla Ángel, Fabre-Alonso Sinuhe, Buendía-Roldán Ivette, Gochicoa-Rangel Laura, López-García Carlos, Radillo-Gil Marian, Hernández Favela Celia Gabriela, Monraz-Perez Sergio, Salas-Hernández Jorge, Santillán-Doherty Patricio
Geriatrics, Palliative Care Clinic, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico.
Otorhinolaryngology Department, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico.
ERJ Open Res. 2024 Aug 5;10(4). doi: 10.1183/23120541.00214-2024. eCollection 2024 Jul.
COVID-19 survivors who were hospitalised continue to experience long-term multisystemic sequelae and symptoms, impacting their health-related quality of life (HRQoL). The complexity of post-COVID-19 conditions underscores the importance of adopting a multidisciplinary, patient-centric approach to ensure ongoing care. This study aims to assess HRQoL and post-COVID symptoms in a cohort of severe COVID-19 survivors depending on their participation in a multidisciplinary programme.
This prospective study was conducted in a post-COVID clinic staffed by a multidisciplinary team (physical rehabilitator, nutritionist, psychologist, including experts in pulmonary rehabilitation, nutrition, psychology and others). Subjects over 18 years old who were hospitalised due to severe COVID-19 during the acute phase and had attended the post-COVID clinic within the first 3 months following discharge were included. Subjects who were unable or unwilling to provide informed consent to participate in the protocol were excluded. Linear mixed-effect models were employed to examine changes in 12-Item Short-Form Health Survey (SF-12) component scores. The resolution of post-COVID symptom clusters was compared using the Cox model.
A total of 730 patients were included, with a mean±sd age of 55.78±15.43 years; 60.55% were male and 90.62% required mechanical ventilation during hospitalisation. Programme attendants demonstrated improved SF-12 physical and mental component scores at 3 and 12 months. A reduction in the prevalence of post-COVID symptoms was observed in both groups, with greater reductions in those attending the programme.
Our study showed that patients enrolled on the multidisciplinary programme experienced improvements in fatigue, musculoskeletal, gastrointestinal, neuropsychiatric and respiratory symptoms, along with enhanced SF-12 mental and physical component scores.
曾住院治疗的新冠病毒病（COVID-19）幸存者仍持续经历多系统长期后遗症和症状，影响其健康相关生活质量（HRQoL）。COVID-19后状况的复杂性凸显了采用多学科、以患者为中心的方法以确保持续护理的重要性。本研究旨在评估一组重症COVID-19幸存者根据其参与多学科项目情况的健康相关生活质量及COVID-19后症状。
本前瞻性研究在一个由多学科团队（物理康复师、营养师、心理学家，包括肺康复、营养、心理学等方面的专家）配备人员的COVID-19后诊所进行。纳入在急性期因重症COVID-19住院且在出院后前3个月内就诊于COVID-19后诊所的18岁以上受试者。排除无法或不愿提供知情同意参与方案的受试者。采用线性混合效应模型检查12项简短健康调查（SF-12）分量表得分的变化。使用Cox模型比较COVID-19后症状群的缓解情况。
共纳入730例患者，平均年龄±标准差为55.78±15.43岁；60.55%为男性，90.62%在住院期间需要机械通气。参与项目者在3个月和12个月时SF-12身体和精神分量表得分有所改善。两组COVID-19后症状的患病率均有所降低，参与项目者的降低幅度更大。
我们的研究表明，参加多学科项目的患者在疲劳、肌肉骨骼、胃肠道、神经精神和呼吸症状方面有所改善，同时SF-12精神和身体分量表得分提高。
