Patel Suhani, Sylvester Karl P, Wu Zhe, Rhamie Serena, Dickel Peter, Maher Toby M, Molyneaux Philip L, Calverley Peter M A, Man William D-C
Harefield Respiratory Research Group, Harefield Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
National Heart and Lung Institute, Imperial College, London, UK.
ERJ Open Res. 2024 Aug 5;10(4). doi: 10.1183/23120541.00227-2024. eCollection 2024 Jul.
In large multinational patient surveys, spirometry (which requires repeated, reproducible maximal efforts) can be associated with cough, breathlessness and tiredness, particularly in those with idiopathic pulmonary fibrosis (IPF). Oscillometry is an effort-independent test of airways resistance and reactance. We hypothesised that oscillometry would take less time to perform and would be associated with reduced symptom burden than spirometry.
Spirometry and oscillometry were performed in 66 participants with IPF and repeated 2 weeks later. We compared time taken to perform tests, symptom burden and test-retest reliability with Bland-Altman plots and intraclass correlation coefficients (ICCs).
Oscillometry took significantly less time to perform than spirometry (mean -4.5 (99% CI -6.0 to -3.0) min) and was associated with lower symptom burden scores for cough (-1.3, 99% CI -1.7 to -0.8), breathlessness (-1.0, 99% CI -1.4 to -0.5), and tiredness (-0.5, 99% CI -0.9 to -0.2). On Bland-Altman analysis, all measures showed good agreement, with narrow limits of agreement and the mean bias lying close to 0 in all cases. The ICCs for forced expiratory volume in 1 s and forced vital capacity were 0.94 and 0.89, respectively, and ranged between 0.70 and 0.90 for oscillometry measures.
Oscillometry is quicker to perform and provokes less symptoms than spirometry in patients with IPF.
在大型跨国患者调查中，肺量计检查（需要反复、可重复的最大努力）可能与咳嗽、呼吸急促和疲劳有关，尤其是在特发性肺纤维化（IPF）患者中。振荡法是一种与努力无关的气道阻力和电抗测试方法。我们假设，与肺量计检查相比，振荡法检查所需时间更短，且症状负担更小。
对66名IPF患者进行了肺量计检查和振荡法检查，并在2周后重复进行。我们使用Bland-Altman图和组内相关系数（ICC）比较了检查所需时间、症状负担和重测信度。
振荡法检查所需时间明显短于肺量计检查（平均少4.5（99%CI -6.0至-3.0）分钟），且咳嗽（-1.3，99%CI -1.7至-0.8）、呼吸急促（-1.0，99%CI -1.4至-0.5）和疲劳（-0.5，99%CI -0.9至-0.2）的症状负担得分更低。在Bland-Altman分析中，所有测量指标均显示出良好的一致性，一致性界限狭窄，所有情况下平均偏差均接近0。1秒用力呼气量和用力肺活量的ICC分别为0.94和0.89，振荡法测量指标的ICC在0.70至0.90之间。
在IPF患者中，振荡法检查比肺量计检查执行速度更快，引发的症状更少。
