Khalifian Saami, McCarthy Alec D, Yoelin Steven G
Dermatology, SOM Aesthetics, San Diego, USA.
Medical Affairs, Merz Aesthetics, Raleigh, USA.
Cureus. 2024 Jul 6;16(7):e63969. doi: 10.7759/cureus.63969. eCollection 2024 Jul.
The two cases discussed in this report investigate the efficacy and safety of a novel injectable therapy for treating neck wrinkles and skin laxity, utilizing a combination of hyperdiluted calcium hydroxylapatite (CaHA), platelet-rich plasma (PRP), and hyaluronidase. Two patients presenting with moderate neck wrinkles and laxity underwent treatment and were evaluated several months later. The combined therapy demonstrated improvements in skin texture and laxity following a single treatment. The rationale behind incorporating PRP and hyaluronidase was their potential to amplify the regenerative effects of CaHA. PRP contains growth factors that stimulate collagen production and tissue regeneration while hyaluronidase facilitates the breakdown of hyaluronic acid, promoting better diffusion and more even product dispersion. The findings from these cases provide emerging preliminary evidence supporting the safety and efficacy of this innovative combination therapy for addressing neck wrinkles and laxity. This is the first documented instance of skin priming CaHA with hyaluronidase and PRP. Future investigations are warranted to explore the application of this treatment for other anatomical regions and to delineate the role of each injected component.
本报告中讨论的两个病例研究了一种新型注射疗法治疗颈部皱纹和皮肤松弛的疗效和安全性，该疗法采用了超稀释羟基磷灰石（CaHA）、富血小板血浆（PRP）和透明质酸酶的组合。两名患有中度颈部皱纹和皮肤松弛的患者接受了治疗，并在数月后进行了评估。联合治疗在单次治疗后显示出皮肤质地和松弛度有所改善。加入PRP和透明质酸酶的理论依据是它们有可能增强CaHA的再生效果。PRP含有刺激胶原蛋白生成和组织再生的生长因子，而透明质酸酶则有助于透明质酸的分解，促进更好的扩散和更均匀的产品分散。这些病例的研究结果提供了新的初步证据，支持这种创新联合疗法治疗颈部皱纹和皮肤松弛的安全性和有效性。这是首次有记录的用透明质酸酶和PRP对CaHA进行皮肤预处理的实例。未来有必要进行进一步研究，以探索这种治疗方法在其他解剖区域的应用，并明确每种注射成分的作用。
