钼酸铜的合成及其对扑热息痛的电化学传感
Synthesis of Copper Molybdate and Its Electrochemical Sensing of Paracetamol.
作者信息
Krisha S G, Menaka S, Celshia Sherin, Selvamani Muthamizh, Suresh Vasugi
机构信息
Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, IND.
Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
出版信息
Cureus. 2024 Jul 5;16(7):e63925. doi: 10.7759/cureus.63925. eCollection 2024 Jul.
Background In recent years, significant advancements have been made in various scientific sectors, particularly in healthcare and pharmaceutical research. This progress has been driven by the development of enhanced sensing materials and methodologies. Electrochemical sensing has become an important tool in detecting and analyzing drug molecules due to its high sensitivity, specificity, and rapid response times. Among various drugs, paracetamol, also known as acetaminophen, is widely used for its analgesic and antipyretic properties. Accurate detection of paracetamol is crucial due to its widespread use and potential for overdose, which can lead to severe liver damage. Copper molybdate (CuMoO) is a transition metal oxide that has garnered attention for its excellent electrical conductivity and electrochemical stability. These properties make it a promising candidate for use in electrochemical sensors. The ability of CuMoO to act as a sensor material is enhanced by its unique structural and morphological characteristics, which can be tailored during synthesis. Aim This study aimed to synthesize CuMoO and investigate its electrochemical sensing capability for the detection of drug molecules, specifically paracetamol. Materials and method CuMoO was synthesized using a precipitation method that did not involve any surfactants. This approach was chosen to simplify the synthesis process and avoid potential contamination from surfactants. The morphology of the synthesized CuMoO nanoparticles was investigated using a field emission scanning electron microscope (FE-SEM). Energy-dispersive X-ray spectroscopy (EDX) confirmed the purity of the CuMoO nanomaterial. Structural analysis was performed using X-ray diffraction (XRD). To evaluate the electrochemical sensing capability of CuMoO for paracetamol, Differential pulse voltammetry (DPV) was employed. DPV is a sensitive electrochemical technique that can detect changes in current response corresponding to the presence of analytes. Results The synthesized CuMoO exhibited a rock-like structure, as revealed by FE-SEM imaging. This morphology is advantageous for electrochemical applications due to the increased surface area available for interaction with analytes. EDX confirmed the purity of the CuMoO nanomaterial, showing no significant impurities. XRD analysis indicated that the CuMoO nanoparticles were crystalline in nature, which is beneficial for consistent and reproducible electrochemical behavior. The DPV analysis demonstrated that the CuMoO sensor exhibited a linear increase in current response with increasing concentrations of paracetamol. This linear relationship indicates that CuMoO₄ is capable of detecting paracetamol effectively, with a strong and quantifiable signal response. Conclusion The CuMoO nanomaterial was successfully synthesized using a simple precipitation method and was characterized by its rock-like morphology and crystalline structure. Electrochemical testing using DPV showed that CuMoO has excellent sensing capabilities for detecting paracetamol, with a clear and linear current response. These findings suggest that CuMoO is a promising electrochemical sensing material for drug detection, potentially offering a reliable and efficient method for monitoring paracetamol and possibly other pharmaceuticals in various settings.
背景 近年来,各个科学领域都取得了重大进展,尤其是在医疗保健和制药研究方面。这一进展得益于增强传感材料和方法的发展。电化学传感因其高灵敏度、特异性和快速响应时间,已成为检测和分析药物分子的重要工具。在各种药物中,对乙酰氨基酚,也称为扑热息痛,因其止痛和解热特性而被广泛使用。由于其广泛使用和过量服用的可能性(这可能导致严重的肝损伤),准确检测对乙酰氨基酚至关重要。钼酸铜(CuMoO)是一种过渡金属氧化物,因其优异的导电性和电化学稳定性而受到关注。这些特性使其成为用于电化学传感器的有前途的候选材料。CuMoO作为传感器材料的能力因其独特的结构和形态特征而得到增强,这些特征可以在合成过程中进行调整。目的 本研究旨在合成CuMoO并研究其对药物分子(特别是对乙酰氨基酚)的电化学传感能力。材料和方法 使用不涉及任何表面活性剂的沉淀法合成CuMoO。选择这种方法是为了简化合成过程并避免表面活性剂的潜在污染。使用场发射扫描电子显微镜(FE-SEM)研究合成的CuMoO纳米颗粒的形态。能量色散X射线光谱(EDX)证实了CuMoO纳米材料的纯度。使用X射线衍射(XRD)进行结构分析。为了评估CuMoO对扑热息痛的电化学传感能力,采用了差分脉冲伏安法(DPV)。DPV是一种灵敏的电化学技术,可以检测与分析物存在相对应的电流响应变化。结果 FE-SEM成像显示,合成的CuMoO呈现出岩石状结构。这种形态对于电化学应用是有利的,因为与分析物相互作用的可用表面积增加。EDX证实了CuMoO纳米材料的纯度,未显示出明显的杂质。XRD分析表明,CuMoO纳米颗粒本质上是结晶的,这有利于一致且可重复的电化学行为。DPV分析表明,CuMoO传感器的电流响应随着扑热息痛浓度的增加呈线性增加。这种线性关系表明CuMoO₄能够有效地检测扑热息痛,具有强烈且可量化的信号响应。结论 使用简单的沉淀法成功合成了CuMoO纳米材料,其特征为岩石状形态和晶体结构。使用DPV进行的电化学测试表明,CuMoO在检测扑热息痛方面具有出色的传感能力,具有清晰的线性电流响应。这些发现表明,CuMoO是一种有前途的用于药物检测的电化学传感材料,可能为在各种环境中监测扑热息痛以及可能的其他药物提供一种可靠且高效的方法。
相似文献
J Mater Sci Mater Electron. 2021
引用本文的文献
本文引用的文献
Br J Clin Pharmacol. 2018-7-20