Harrison Lucas M, Hallac Rami R, Seaward James, Kane Alex A, Park Yong-Jong
Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Analytical Imaging and Modeling Center, Children's Medical Center, Dallas, TX, USA.
Cleft Palate Craniofac J. 2024 Aug 6:10556656241271672. doi: 10.1177/10556656241271672.
Alveolar bone grafting (ABG) in bilateral cleft lip and palate (BCLP) patients provides a reconstructive challenge. We present a novel technique of combining autologous iliac crest bone graft (ICBG) with recombinant human bone morphogenic protein 2 (rhBMP-2) and cellular bone matrix (CBM) for ABG in BCLP patients. Complete bone fill occurred in 90% of patients, with 100% having bilateral canine eruption. No patients required repeat ABG, and no significant complications were reported. The alveolar cleft gap volume significantly decreased with an improvement of 75.87%. ABG with autologous ICBG with rhBMP-2 and CBM is an effective technique for patients with BCLP.
双侧唇腭裂（BCLP）患者的牙槽骨植骨（ABG）是一项重建挑战。我们提出了一种将自体髂嵴骨移植（ICBG）与重组人骨形态发生蛋白2（rhBMP-2）和细胞骨基质（CBM）相结合的新技术，用于BCLP患者的ABG。90%的患者实现了完全骨填充，100%的患者双侧尖牙萌出。没有患者需要重复ABG，也没有报告严重并发症。牙槽裂间隙体积显著减小，改善率为75.87%。自体ICBG联合rhBMP-2和CBM进行ABG对BCLP患者是一种有效的技术。
