Playfair J H, Dockrell H, Taverne J
Immunol Lett. 1985;11(3-4):233-7. doi: 10.1016/0165-2478(85)90173-7.
Experiments with malaria in mice suggest that protective immunity depends not only on antibody but also on activation of macrophages. Activated macrophages may cause intra-erythrocytic death of parasites by releasing reactive oxygen intermediates and/or tumour necrosis factor. Macrophage activation for both types of product correlates well with the timing of recovery in a range of different malaria infections and in mice protected by vaccination.
对小鼠进行的疟疾实验表明，保护性免疫不仅取决于抗体，还取决于巨噬细胞的激活。活化的巨噬细胞可能通过释放活性氧中间体和/或肿瘤坏死因子导致寄生虫在红细胞内死亡。在一系列不同的疟疾感染以及通过疫苗接种得到保护的小鼠中，这两种产物的巨噬细胞活化与恢复时间密切相关。
