CFH 基因 rs1410996 多态性与云南汉族原发性高血压的相关性研究。
Relationship between rs1410996 polymorphism of CFH gene and essential hypertension patients of Han from Yunnan Province.
机构信息
Department of Cardiovascular Medicine, Yancheng No.1 People's Hospital, Affiliated Hospital of Medical School, Nanjing University, Yancheng, China.
Department of Radiology, 2nd Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
出版信息
Mol Biol Rep. 2024 Aug 6;51(1):888. doi: 10.1007/s11033-024-09819-5.
OBJECTIVE
To explore the relationship between rs1410996 polymorphism of CFH gene and essential hypertension (EH) in the Yunnan Han population.
METHODS
rs1410996 of CFH gene was genotyped based on the collected clinical phenotypes of the EH patients (n = 520) and healthy people (n = 494).
RESULTS
On the genotype model and dominance model, there was no relationship between rs1410996 of CFH gene and EH after adjustment (P > 0.05). On the dominance model of male EH patients, the pulse pressure (PP) level of CC genotype carriers was higher than that of (CT + TT) genotype carriers after adjustment (P < 0.05).
CONCLUSION
rs1410996 of CFH gene has no correlation with the genetic susceptibility to EH in the Yunnan Han population, but it is related to the PP level in male patients.
目的
探讨云南汉族人群 CFH 基因 rs1410996 多态性与原发性高血压（EH）的关系。
方法
根据 EH 患者（n=520）和健康对照者（n=494）的临床表型，对 CFH 基因 rs1410996 进行基因分型。
结果
在调整后，CFH 基因 rs1410996 的基因型模型和显性模型与 EH 均无关联（P>0.05）。在男性 EH 患者的显性模型中，CC 基因型携带者的脉压（PP）水平高于（CT+TT）基因型携带者（P<0.05）。
结论
CFH 基因 rs1410996 与云南汉族人群 EH 的遗传易感性无关，但与男性患者的 PP 水平有关。
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