Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, United States.
Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, Massachusetts, United States.
Physiology (Bethesda). 2025 Jan 1;40(1):0. doi: 10.1152/physiol.00022.2024. Epub 2024 Aug 6.
Preterm birth remains a worldwide health concern because of ongoing challenges in prediction and prevention. Current predictors are limited by poor performance, need for invasive sampling, and an inability to identify patients in a timely fashion to allow for effective intervention. The multiple etiologies of preterm birth often have an inflammatory component. Thus, a deeper understanding of the inflammatory mechanisms involved in preterm birth may provide opportunities to identify new predictors of preterm birth. This review discusses the multiple etiologies of preterm birth, their links to inflammation, current predictors available, and new directions for the field.
早产仍然是一个全球性的健康问题，因为在预测和预防方面仍然存在挑战。目前的预测方法受到性能不佳、需要有创性采样以及无法及时识别患者以进行有效干预等因素的限制。早产的多种病因通常都具有炎症成分。因此，深入了解早产中涉及的炎症机制可能为识别早产的新预测指标提供机会。本综述讨论了早产的多种病因、它们与炎症的联系、现有的预测指标以及该领域的新方向。
