Straube E, Broschewitz U, Naumann G, Schill H
J Hyg Epidemiol Microbiol Immunol. 1985;29(4):435-46.
Autovaccination of rats with chronic pyelonephritis carried out approximately two months after the onset of infection does not result in an improved histological picture in the infected but can prevent destructive processes in the controlateral kidney. Cyclophosphamide administered in three doses of 30 mg/kg simultaneously with autovaccination slightly modulates the immune response to the infectious strain. The temporal relationship between immunization and cyclophosphamide administration determines the mode of action of cyclophosphamide. In the present experiment, the concept of Miller has not proved to be applicable. Cyclophosphamide administration causes a distinct increase in inflammatory processes in the kidney. Should an enhancement phenomenon be involved in the bacterial infection of the kidney, of which we have found no proof, cyclophosphamide therapy as it was used in the present study would not result in its removal and thus in improved elimination of the infectious organism. Additional experiments are required to determine whether animals subjected to autovaccination are protected against a new episode of urinary tract infection.
大鼠在感染慢性肾盂肾炎约两个月后进行自身接种，虽不会改善感染侧肾脏的组织学状况，但可预防对侧肾脏的破坏过程。在自身接种同时给予三次剂量为30mg/kg的环磷酰胺，可轻微调节对感染菌株的免疫反应。免疫接种与环磷酰胺给药的时间关系决定了环磷酰胺的作用方式。在本实验中，米勒的概念未被证明适用。给予环磷酰胺会导致肾脏炎症过程明显增加。若肾脏细菌感染存在我们未找到证据的增强现象，本研究中使用的环磷酰胺疗法不会消除该现象，从而不会改善感染病原体的清除情况。需要进行额外实验以确定接受自身接种的动物是否能预防新的尿路感染发作。
