Miller T E, Burnham S, North J D
Clin Exp Immunol. 1976 May;24(2):336-45.
The role of the immune response in pyelonephritis was investigated by manipulation of the host's immune capacity using the immunosuppressive drugs 6-mercaptopurine, cyclophosphamide and thiamphenicol. Treatment with 6-mercaptopurine depressed the humoral immune response but did not have an adverse effect on the course of renal infection. Thiamphenicol administration prevented the development of pathological lesions but this was due to the anti-bacterial activity of thiamphenicol and not to its immunosuppressive activity. Pyelonephritic animals treated with cyclophosphamide did not produce anti-bacterial antibody. Despite this, cyclophosphamide-treated animals were able to eliminate organisms more readily from the infected kidney than untreated animals with a normal humoral immune response. We believe that blocking of the phenomenon of immunological enhancement explains these unexpected results and that the immune response to renal infection may have an immunoenhancing role protecting the bacterial cell from otherwise effective host defence mechanisms.
通过使用免疫抑制药物6-巯基嘌呤、环磷酰胺和甲砜霉素来调控宿主的免疫能力，研究免疫反应在肾盂肾炎中的作用。用6-巯基嘌呤治疗可抑制体液免疫反应，但对肾脏感染的病程没有不利影响。给予甲砜霉素可防止病理损伤的发展，但这是由于甲砜霉素的抗菌活性，而非其免疫抑制活性。用环磷酰胺治疗的肾盂肾炎动物不产生抗菌抗体。尽管如此，与具有正常体液免疫反应的未治疗动物相比，用环磷酰胺治疗的动物能够更轻易地从受感染的肾脏中清除细菌。我们认为，免疫增强现象的阻断解释了这些意外结果，并且对肾脏感染的免疫反应可能具有免疫增强作用，可保护细菌细胞免受原本有效的宿主防御机制的影响。
