Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China.
Eur J Immunol. 2024 Nov;54(11):e2451093. doi: 10.1002/eji.202451093. Epub 2024 Aug 6.
Immunosenescence, the aging of the immune system, leads to functional deficiencies, particularly in T cells, which undergo significant changes. While numerous studies have investigated age-related T-cell phenotypes in healthy aging, senescent T cells have also been observed in younger populations during pathological conditions like cancer. This review summarizes the recent advancements in age-associated alterations and markers of T cells, mechanisms, and the relationship between senescent T cells and the tumor microenvironment. We also discuss potential strategies for targeting senescent T cells to prevent age-related diseases and enhance tumor immunotherapy efficacy.
免疫衰老，即免疫系统的老化，导致功能缺陷，特别是 T 细胞发生显著变化。虽然许多研究都调查了健康衰老过程中与年龄相关的 T 细胞表型，但在癌症等病理条件下，也观察到了年轻人群中的衰老 T 细胞。本综述总结了 T 细胞与年龄相关的改变和标志物、机制以及衰老 T 细胞与肿瘤微环境之间关系的最新进展。我们还讨论了针对衰老 T 细胞的潜在策略，以预防与年龄相关的疾病并增强肿瘤免疫治疗的疗效。
