Perl A, Gonzalez-Cabello R, Nékám K, Gergely P, Fehér J
J Clin Lab Immunol. 1985 Nov;18(3):119-22.
The effect of thymopoietin penta- (TP-5), tetra-(TP-4), and tripeptides (TP-3) was studied on the depressed lectin-dependent cell-mediated cytotoxicity (LDCC) against adherent HEp-2 target cells by peripheral blood mononuclear cells from patients with active systemic lupus erythematosus (SLE). LDCC activity was evaluated by detachment from the monolayer of 3H-thymidine-prelabelled HEp-2 cells in the presence of concanavalin A (Con A). While 10(-5)M TP-3 moderated the depression, 10(-5) M TP-5 strongly enhanced LDCC activity in SLE patients up to the normal level. On the other hand, LDCC activity by normal donors was not influenced by TP-3 and TP-5. TP-4 had no major effect either in control or in SLE patients. In parallel experiments none of the thymopoietin peptides affected the Con A-induced suppressor activity on the blastogenesis of lymphocytes. A selective immunostimulatory effect of TP-3 and TP-5 on the generation of LDCC effector cells in patients with SLE is suggested.
研究了胸腺生成素五肽（TP - 5）、四肽（TP - 4）和三肽（TP - 3）对活动期系统性红斑狼疮（SLE）患者外周血单个核细胞针对贴壁HEp - 2靶细胞的凝集素依赖性细胞介导的细胞毒性（LDCC）降低的影响。通过在伴刀豆球蛋白A（Con A）存在的情况下使预标记有³H - 胸腺嘧啶核苷的HEp - 2细胞单层脱离来评估LDCC活性。虽然10⁻⁵M的TP - 3减轻了这种降低，但10⁻⁵M的TP - 5强烈增强了SLE患者的LDCC活性，使其达到正常水平。另一方面，正常供体的LDCC活性不受TP - 3和TP - 5的影响。TP - 4在对照组或SLE患者中均无主要作用。在平行实验中，胸腺生成素肽均未影响Con A诱导的对淋巴细胞增殖的抑制活性。提示TP - 3和TP - 5对SLE患者LDCC效应细胞的产生具有选择性免疫刺激作用。
