Vieira-Santos Flaviane, Morais de Medeiros Brito Ramayana, de Almeida Lopes Camila, Leal-Silva Thais, Nascimento Souza Jorge Lucas, Oliveira Amorim Chiara Cássia, Loiola Ruas Ana Cristina, de Lima Silva Padrão Luiza, Kraemer Lucas, Silva Oliveira Fabrício Marcus, Caliari Marcelo Vidigal, Russo Remo Castro, Fujiwara Ricardo Toshio, Dias Magalhães Luisa Mourão, Bueno Lilian Lacerda
Laboratory of Immunobiology and Control of Parasites, Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Laboratory of Protozooses, Department of General Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Heliyon. 2024 Jul 2;10(14):e33739. doi: 10.1016/j.heliyon.2024.e33739. eCollection 2024 Jul 30.
Alveolar macrophages (AM) and monocytes (MO) are myeloid cells that play a substantial role in the development and establishment of the innate and adaptive immune response. These cells are crucial for host defense against various pathogens, but their role in malaria is poorly understood. Here, we characterize the dynamics of AMs and recruited leukocytes subpopulations in the airways during experimental NK65-NY (PbNK65). We show that PbNK65 infection induces an increased pulmonary vascular permeability that provides Ly6C MOs, neutrophils (NEU), CD4 and CD8 lymphocytes in the airways. This inflammatory environment resulted in an increase in the population and alteration of the activation state of the AMs. Taken together, the data presented provide new insights into airway inflammation associated with pulmonary malaria.
肺泡巨噬细胞（AM）和单核细胞（MO）是髓系细胞，在先天性和适应性免疫反应的发展和建立中发挥重要作用。这些细胞对于宿主抵御各种病原体至关重要，但其在疟疾中的作用却知之甚少。在此，我们描述了实验性NK65-NY（PbNK65）感染期间气道中AMs和募集的白细胞亚群的动态变化。我们发现，PbNK65感染会导致肺血管通透性增加，从而使气道中出现Ly6C MO、中性粒细胞（NEU）、CD4和CD8淋巴细胞。这种炎症环境导致AMs数量增加以及其激活状态发生改变。综上所述，所呈现的数据为与肺部疟疾相关的气道炎症提供了新的见解。
