Gong Huankai, Chen Yao, Chen Meiling, Li Jiankang, Zhang Hong, Yan Shijiao, Lv Chuanzhu
Emergency and Trauma College, Hainan Medical University, Haikou, China.
Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou, China.
Front Med (Lausanne). 2022 Nov 14;9:1043859. doi: 10.3389/fmed.2022.1043859. eCollection 2022.
The introduction of the Sepsis 3.0 guidelines in 2016 improved our understanding of sepsis diagnosis and therapy. Personalized treatment strategies and nursing methods for sepsis patients are recommended in the "Save Sepsis Campaign" in 2021. However, mortality in sepsis patients remains high. Patients with sepsis-related acute respiratory distress syndrome account for around 30% of them, with fatality rates ranging from 30 to 40%. Pathological specimens from individuals with sepsis-related ARDS frequently demonstrate widespread alveolar damage, and investigations have revealed that pulmonary epithelial and pulmonary endothelial injury is the underlying cause. As a result, the purpose of this work is to evaluate the mechanism and research progress of pulmonary epithelial and pulmonary endothelial damage in sepsis-related ARDS, which may provide new directions for future research, diagnosis, and therapy.
2016年《脓毒症3.0指南》的推出增进了我们对脓毒症诊断和治疗的理解。2021年的“拯救脓毒症运动”推荐了针对脓毒症患者的个性化治疗策略和护理方法。然而，脓毒症患者的死亡率仍然很高。脓毒症相关急性呼吸窘迫综合征患者约占其中的30%，死亡率在30%至40%之间。脓毒症相关急性呼吸窘迫综合征患者的病理标本经常显示广泛的肺泡损伤，研究表明肺上皮和肺内皮损伤是其根本原因。因此，这项工作的目的是评估脓毒症相关急性呼吸窘迫综合征中肺上皮和肺内皮损伤的机制及研究进展，这可能为未来的研究、诊断和治疗提供新的方向。
