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恩替卡韦联合短期每日两次使用β干扰素成功治疗乙肝病毒再激活

Successful Treatment of Hepatitis B Virus Reactivation With a Combination of Entecavir and Short-Term Administration of Interferon-β Twice per Day.

作者信息

Sasaki Kyo, Hirose Tadashi, Suetsugu Yoshimasa, Yabushita Kazuhisa, Sakaguchi Kosaku

机构信息

Gastroenterology and Hepatology, Kawasaki Medical School, Kurashiki, JPN.

Hematology, Itoshima Medical Association Hospital, Fukuoka, JPN.

出版信息

Cureus. 2024 Jul 6;16(7):e63978. doi: 10.7759/cureus.63978. eCollection 2024 Jul.

DOI:10.7759/cureus.63978
PMID:39109128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300176/
Abstract

Hepatitis B virus (HBV) reactivation-related hepatitis is likely to progress to acute liver failure, with high morbidity and mortality, even when nucleoside analogs are administered after the onset of hepatitis. We report a case of adult T-cell leukemia/lymphoma (ATLL) with the development of HBV reactivation-related hepatitis during chemotherapy and successful treatment by a combination of entecavir and short-term intravenous administration of interferon (IFN)-β 3 MIU twice per day. This outcome suggests that this combination therapy has a potent effect in rapidly suppressing HBV replication in the early phase of hepatitis and may be effective and safe for the treatment of HBV reactivation-related hepatitis.

摘要

乙型肝炎病毒（HBV）再激活相关肝炎即使在肝炎发作后给予核苷类似物，仍可能进展为急性肝衰竭，具有高发病率和死亡率。我们报告一例成人T细胞白血病/淋巴瘤（ATLL）患者，在化疗期间发生HBV再激活相关肝炎，并通过恩替卡韦与短期静脉注射干扰素（IFN）-β 3MIU每日两次联合成功治疗。这一结果表明，这种联合疗法在肝炎早期能有效快速抑制HBV复制，对于治疗HBV再激活相关肝炎可能有效且安全。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4ff/11300176/71715944bc75/cureus-0016-00000063978-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4ff/11300176/71715944bc75/cureus-0016-00000063978-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4ff/11300176/71715944bc75/cureus-0016-00000063978-i01.jpg

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本文引用的文献

1
Japan Society of Hepatology Guidelines for the Management of Hepatitis B Virus Infection: 2019 update.日本肝脏学会乙型肝炎病毒感染管理指南：2019年更新版
Hepatol Res. 2020 Aug;50(8):892-923. doi: 10.1111/hepr.13504. Epub 2020 Jul 15.
2
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection.EASL 2017 临床实践指南：乙型肝炎病毒感染管理。
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Long-Term Outcome of Sequential Therapy with Lamivudine Followed by Interferon-β in Nucleoside-Naive, Hepatitis B e-Antigen-Positive Patients with Chronic Hepatitis B Virus Genotype C Infection.
核苷初治、乙肝e抗原阳性的慢性乙型肝炎病毒C基因型感染患者中，先使用拉米夫定后使用β干扰素序贯治疗的长期疗效。
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4
Entecavir vs lamivudine for prevention of hepatitis B virus reactivation among patients with untreated diffuse large B-cell lymphoma receiving R-CHOP chemotherapy: a randomized clinical trial.恩替卡韦与拉米夫定预防未治疗弥漫性大 B 细胞淋巴瘤接受 R-CHOP 化疗患者乙型肝炎病毒再激活：一项随机临床试验。
JAMA. 2014 Dec 17;312(23):2521-30. doi: 10.1001/jama.2014.15704.
5
Interferon-beta plus ribavirin therapy can be safely and effectively administered to elderly patients with chronic hepatitis C.干扰素β联合利巴韦林疗法可安全有效地应用于老年慢性丙型肝炎患者。
J Infect Chemother. 2014 Aug;20(8):489-92. doi: 10.1016/j.jiac.2014.04.009. Epub 2014 May 22.
6
Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy.拉米夫定、干扰素-β和泼尼松龙三联疗法治疗妊娠慢性乙型肝炎急性加重。
Hepatol Res. 2013 Apr;43(4):425-9. doi: 10.1111/j.1872-034X.2012.01077.x.
7
Increase in platelet count based on inosine triphosphatase genotype during interferon beta plus ribavirin combination therapy.基于肌苷三磷酸酶基因型的血小板计数增加在干扰素β联合利巴韦林联合治疗期间。
J Gastroenterol Hepatol. 2012 Sep;27(9):1461-6. doi: 10.1111/j.1440-1746.2012.07171.x.
8
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Hepatitis B virus reactivation in lymphoma patients with prior resolved hepatitis B undergoing anticancer therapy with or without rituximab.既往乙肝已缓解的淋巴瘤患者在接受含或不含利妥昔单抗的抗癌治疗过程中发生的乙肝病毒再激活。
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