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一名感染HIV/AIDS和猴痘患者的罕见库尼斯综合征病例报告。

A Report of a Rare Case of Kounis Syndrome in a Patient With HIV/AIDS and Mpox.

作者信息

Jha Vivek, Jha Saroj K, Aryal Badri, Dhungel Swati, Jha Supriya, Brock Max

机构信息

Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

Internal Medicine, Tribhuvan University Institute of Medicine, Kathmandu, NPL.

出版信息

Cureus. 2024 Jul 6;16(7):e63957. doi: 10.7759/cureus.63957. eCollection 2024 Jul.

DOI:10.7759/cureus.63957
PMID:39109131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300188/
Abstract

Kounis syndrome (KS) is defined as the occurrence of acute coronary syndrome due to coronary artery spasm in a patient with an allergic reaction. Antibiotics are the most common trigger for KS. In this case report, we present a 45-year-old man with HIV/AIDS who was being managed for mpox and developed chest pain and hypotension during vancomycin infusion, which was complicated by the development of ST-elevation myocardial infarction (STEMI). His left heart catheterization showed normal coronaries with the resolution of ECG changes and symptoms upon discontinuing vancomycin.

摘要

库尼斯综合征（KS）定义为在过敏反应患者中因冠状动脉痉挛而发生的急性冠状动脉综合征。抗生素是KS最常见的诱因。在本病例报告中，我们介绍了一名45岁的艾滋病毒/艾滋病患者，他正在接受猴痘治疗，在输注万古霉素期间出现胸痛和低血压，并并发ST段抬高型心肌梗死（STEMI）。他的左心导管检查显示冠状动脉正常，停用万古霉素后心电图改变和症状消失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7d/11300188/4f698673361b/cureus-0016-00000063957-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7d/11300188/0c4e07762b55/cureus-0016-00000063957-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7d/11300188/4f698673361b/cureus-0016-00000063957-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7d/11300188/0c4e07762b55/cureus-0016-00000063957-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f7d/11300188/4f698673361b/cureus-0016-00000063957-i02.jpg

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A Report of a Rare Case of Kounis Syndrome in a Patient With HIV/AIDS and Mpox.一名感染HIV/AIDS和猴痘患者的罕见库尼斯综合征病例报告。
Cureus. 2024 Jul 6;16(7):e63957. doi: 10.7759/cureus.63957. eCollection 2024 Jul.
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本文引用的文献

1
The curious case of Kounis syndrome: exploring clinical manifestations and management in the presence of nonobstructive coronary arteries.库尼斯综合征的奇闻：探讨非阻塞性冠状动脉情况下的临床表现及处理
Glob Cardiol Sci Pract. 2024 Mar 3;2024(2):e202414. doi: 10.21542/gcsp.2024.14.
2
Kounis Syndrome as a Cause of Myocardial Infarction with Nonobstructive Coronary Arteries.以冠状动脉无阻塞性病变的心肌梗死为表现的库尼氏综合征
Kans J Med. 2024 Apr 26;17(2):34-35. doi: 10.17161/kjm.vol17.21486. eCollection 2024.
3
Kounis syndrome: ST elevations in the setting of anaphylaxis.
库尼综合征：过敏反应时出现的ST段抬高。
J Allergy Clin Immunol Glob. 2023 Jul 24;2(4):100152. doi: 10.1016/j.jacig.2023.100152. eCollection 2023 Nov.
4
Intraoperative cardiac arrest due to allergic acute coronary syndrome (Kounis syndrome) triggered by cephalosporin.因头孢菌素引发的过敏急性冠状动脉综合征（Kounis 综合征）导致的术中心搏骤停。
Ann Card Anaesth. 2023 Apr-Jun;26(2):219-222. doi: 10.4103/aca.aca_302_20.
5
Kounis Syndrome: A Case of Vancomycin-Associated Coronary Artery Vasospasm Resulting in Myocardial Infarction.库尼斯综合征：一例由万古霉素相关冠状动脉痉挛导致心肌梗死的病例。
CJC Open. 2021 Nov 17;4(3):337-339. doi: 10.1016/j.cjco.2021.11.003. eCollection 2022 Mar.
6
Vancomycin-induced Kounis Syndrome.万古霉素诱导的 Kounis 综合征。
Am J Emerg Med. 2019 Sep;37(9):1806.e3-1806.e5. doi: 10.1016/j.ajem.2019.06.004. Epub 2019 Jun 3.
7
Vancomycin-induced coronary artery spasm: a case of Kounis syndrome.万古霉素诱发的冠状动脉痉挛：一例库尼综合征病例
BMJ Case Rep. 2018 Jan 17;2018:bcr-2017-222846. doi: 10.1136/bcr-2017-222846.
8
Interesting presentation of Kounis syndrome secondary to amoxicillin/ clavulanate use: Coronary vasospasm and simultaneous appropriate implantable defibrillator shock.阿莫西林/克拉维酸使用继发库尼综合征的有趣表现：冠状动脉痉挛与同时发生的合适植入式心律转复除颤器电击
Turk Kardiyol Dern Ars. 2017 Jul;45(5):466-469. doi: 10.5543/tkda.2017.38845.
9
Kounis syndrome: A review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome.库尼斯综合征：关于过敏性急性冠状动脉综合征的流行病学、诊断结果、管理及并发症的综述文章
Int J Cardiol. 2017 Apr 1;232:1-4. doi: 10.1016/j.ijcard.2017.01.124. Epub 2017 Jan 27.
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Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management.库尼斯综合征：流行病学、发病机制、诊断及治疗管理的最新进展
Clin Chem Lab Med. 2016 Oct 1;54(10):1545-59. doi: 10.1515/cclm-2016-0010.