Wang Su, Zhao Yijing, Yang Yu, Pan Yuting, Wang Kun
Department of Endocrinology Affiliated Jiangning Hospital of Nanjing Medical University Nanjing China.
Clin Case Rep. 2024 Aug 5;12(8):e9234. doi: 10.1002/ccr3.9234. eCollection 2024 Aug.
This case highlights the importance of carefully weighing the benefits and risks of beta-adrenergic blockade therapy based on symptoms, echocardiography, and BNP values in thyroid storm patients.
Thyroid storm is a rare but life-threatening condition in thyrotoxic patients. The keys to successful management of thyroid storm are early diagnosis, immediate anti-thyroid medications, and preventing multiorgan failure. We present a case of thyroid storm, acute decompensated heart failure, and atrial fibrillation with rapid ventricular response. We initiated propranolol to control thyroid storm. Soon after, the patient developed more severe heart failure with decreased ejection fraction (EF). We switched to diltiazem to control tachycardia, but the therapeutic effect was unsatisfactory. Finally, we used an ultra-short-acting beta-adrenergic blockade with strict monitoring of heart rate and echocardiography, and the patient survived. Beta-adrenergic blockades should be used cautiously in thyroid storm, especially patients with severe heart failure. Echocardiography can be used to aid in selection and monitoring of therapeutic drugs and prognostic outcomes in patients with thyroid storm and heart failure.
该病例强调了在甲状腺危象患者中,根据症状、超声心动图和脑钠肽值仔细权衡β-肾上腺素能阻滞剂治疗的利弊的重要性。
甲状腺危象是甲状腺毒症患者中一种罕见但危及生命的病症。成功管理甲状腺危象的关键在于早期诊断、立即使用抗甲状腺药物以及预防多器官功能衰竭。我们报告一例甲状腺危象、急性失代偿性心力衰竭和伴有快速心室反应的心房颤动病例。我们开始使用普萘洛尔控制甲状腺危象。此后不久,患者出现更严重的心力衰竭,射血分数(EF)降低。我们改用维拉帕米控制心动过速,但治疗效果不理想。最后,我们使用超短效β-肾上腺素能阻滞剂并严格监测心率和超声心动图,患者得以存活。β-肾上腺素能阻滞剂在甲状腺危象中应谨慎使用,尤其是严重心力衰竭患者。超声心动图可用于辅助选择和监测甲状腺危象和心力衰竭患者的治疗药物及预后结果。