Mansoor Taha, Kaur Jaspreet, Randhawa Maninder, Rai Anand, Yu Dylan, Khan Fatima Iqbal, Koshy Santhosh
Department of Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, USA.
Department of Cardiology, Ascension Borgess Hospital, Kalamazoo, USA.
Eur J Case Rep Intern Med. 2024 Nov 4;11(12):004958. doi: 10.12890/2024_004958. eCollection 2024.
Thyroid storm is a life-threatening condition with often severe cardiac implications. Correct treatment choices can vary depending on underlying cardiac systolic function.
We present a case of a 47-year-old male with untreated Grave's disease who presented with a thyroid storm. After propranolol administration, he experienced a cardiac arrest with the return of spontaneous circulation after cardiopulmonary resuscitation. Further evaluation revealed severe thyroid-induced cardiomyopathy with left ventricular ejection fraction of 15-20%, which had decreased from 60-65% over one year. The patient was discharged home on hospital day 8 after an unremarkable ischaemic work-up. He experienced a full cardiac systolic function recovery with an ejection fraction of 60-65% at the 90-day follow-up.
Thyroid storm can present with overt or subclinical heart failure. Prompt evaluation of cardiac systolic function with a transthoracic echocardiogram before beta-blockade and the use of shorter-acting beta blockers can prevent devastating suppression of myocardial function.
Despite being first-line therapy, beta blockers can be beneficial or devastating in thyroid storm patients depending on the presence of low cardiac output or high cardiac output heart failure.Clinical awareness, prompt echocardiography and the use of shorter half-life beta blockers can prevent rapid cardiac deterioration in thyroid storm patients.
甲状腺风暴是一种危及生命的疾病,常伴有严重的心脏问题。正确的治疗选择可能因潜在的心脏收缩功能而异。
我们报告一例47岁未治疗的格雷夫斯病男性患者,其出现甲状腺风暴。给予普萘洛尔后,他发生心脏骤停,心肺复苏后恢复自主循环。进一步评估发现严重的甲状腺诱导型心肌病,左心室射血分数为15%-20%,较一年前的60%-65%有所下降。患者在进行了无异常的缺血检查后,于住院第8天出院。在90天随访时,他的心脏收缩功能完全恢复,射血分数为60%-65%。
甲状腺风暴可表现为显性或亚临床心力衰竭。在使用β受体阻滞剂前,通过经胸超声心动图及时评估心脏收缩功能,并使用短效β受体阻滞剂,可防止心肌功能受到严重抑制。
尽管β受体阻滞剂是一线治疗药物,但在甲状腺风暴患者中,根据是否存在低心输出量或高心输出量心力衰竭,其可能有益也可能造成严重后果。临床意识、及时进行超声心动图检查以及使用半衰期较短的β受体阻滞剂,可防止甲状腺风暴患者心脏功能迅速恶化。