Lucas Michaela, Mak Hugo W F, Lee Jasmine T Y, Kulkarni Rishabh, Chan Sophia S C, Li Philip H
Immunology Department, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Medical School, University of Western Australia, Perth, Western Australia, Australia.
Allergy. 2025 Feb;80(2):525-533. doi: 10.1111/all.16270. Epub 2024 Aug 7.
The consequences of drug allergy remain a global health concern. Drug allergy is often a neglected topic and many non-specialists lack sufficient knowledge or confidence in evaluating or managing this common condition. Evidence-based interventions to better equip non-specialists to tackle drug allergy are needed. The aim of the study is to evaluate the effectiveness of an intensive educational course on drug allergy knowledge and practice of non-specialists.
A randomized crossover trial (NCT06399601) was conducted among practicing physicians and nurses participating in an intensive drug allergy course-Advances in Drug Allergy & Penicillin Testing (ADAPT). Participants' baseline knowledge and self-reported practices were assessed with standardized questionnaires (scored from 0 to 100, with "satisfactory" defined as ≥60/100). Participants were randomized into two cohorts and attended ADAPT at different time points. Serial responses before and after the course were compared within and between cohorts.
Seventy participants (25 physicians, 45 nurses) randomized into two groups completed the course. Baseline drug allergy knowledge (58.0 ± 19.9) and self-reported practice (36.9 ± 24.3) were unsatisfactory among non-specialists, with significantly lower scores from nurses than physicians in both domains (knowledge: 49.0 ± 17.4 vs. 74.0 ± 12.7; practice: 32.1 ± 21.3 vs. 53.3 ± 23.1; all p < 0.001). Following completion of ADAPT, participants demonstrated significant improvements in knowledge (58.0 ± 19.9 vs. 77.7 ± 15.9, p < 0.001) and self-reported practice (36.9 ± 24.3 vs. 71.0 ± 20.2, p < 0.001). All participants (100%) and 99% of participants agreed that the course improved their clinical knowledge and practice, respectively.
ADAPT, an intensive drug allergy educational course was effective in improving drug allergy knowledge and practice for non-specialists. Further longitudinal studies are required to evaluate long-term impact.
药物过敏的后果仍是全球关注的健康问题。药物过敏往往是一个被忽视的话题，许多非专科医生在评估或处理这种常见病症时缺乏足够的知识或信心。需要有循证干预措施，以使非专科医生更好地应对药物过敏。本研究的目的是评估一门强化教育课程对非专科医生药物过敏知识及实践的有效性。
在参加强化药物过敏课程——药物过敏与青霉素检测进展（ADAPT）的执业医生和护士中进行了一项随机交叉试验（NCT06399601）。通过标准化问卷评估参与者的基线知识和自我报告的实践情况（评分范围为0至100，“满意”定义为≥60/100）。参与者被随机分为两组，并在不同时间点参加ADAPT课程。比较两组内及两组间课程前后的系列反应。
随机分为两组的70名参与者（25名医生，45名护士）完成了课程。非专科医生的基线药物过敏知识（58.0±19.9）和自我报告的实践情况（36.9±24.3）不理想，在这两个方面护士的得分均显著低于医生（知识：49.0±17.4对74.0±12.7；实践：32.1±21.3对53.3±23.1；所有p<0.001）。完成ADAPT课程后，参与者在知识（58.0±19.9对77.7±15.9，p<0.001）和自我报告的实践情况（36.9±24.3对71.0±20.2，p<0.001）方面有显著改善。所有参与者（100%）和99%的参与者分别认为该课程提高了他们的临床知识和实践能力。
ADAPT这门强化药物过敏教育课程对提高非专科医生的药物过敏知识及实践有效。需要进一步进行纵向研究以评估长期影响。
