产前重金属暴露与儿童哮喘、过敏性鼻炎、特应性皮炎：系统评价和荟萃分析。
Prenatal heavy metal exposure and pediatric asthma, allergic rhinitis, atopic dermatitis: a systematic review and meta-analysis.
机构信息
Department of Otolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China.
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China.
出版信息
Expert Rev Clin Immunol. 2024 Nov;20(11):1401-1409. doi: 10.1080/1744666X.2024.2390024. Epub 2024 Aug 12.
OBJECTIVE
We review the prevalence of allergic diseases in children across prenatal exposures to heavy metals.
METHODS
This systematic review and meta-analysis is registered in the PROSPERO database (CRD42023478471). A comprehensive search of PubMed, Web of Science, Medline and Cochrane library was conducted from the database inception until 31 October 2023. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to assess the quality of included studies. We used a random-effects model to summarize the effects from the studies.
RESULTS
A total of 16 studies were included, 120,065 mother-child pairs enrolled. The NOS scores indicated that the quality of the literature included in the study was of a high standard.
CONCLUSION
The final results indicate that prenatal exposure to Pb increased the incidence of wheeze and Eczema in infants, and exposure to Ni and CD increased the incidence of AD in infants.
目的
我们回顾了产前接触重金属与儿童过敏疾病患病率之间的关系。
方法
本系统评价和荟萃分析已在 PROSPERO 数据库（CRD42023478471）中注册。从数据库建立到 2023 年 10 月 31 日，我们对 PubMed、Web of Science、Medline 和 Cochrane 图书馆进行了全面检索。采用纽卡斯尔-渥太华质量评估量表（NOS）对纳入研究的质量进行评估。我们使用随机效应模型对研究结果进行汇总。
结果
共纳入 16 项研究，涉及 120065 对母婴。NOS 评分表明，研究中纳入文献的质量标准较高。
结论
最终结果表明，产前接触 Pb 会增加婴儿喘息和湿疹的发病率，而接触 Ni 和 CD 会增加婴儿 AD 的发病率。
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