Barttelbort S W, O'Leary M J, Schneider J, Woodruff W
Microsurgery. 1985;6(4):233-6. doi: 10.1002/micr.1920060408.
Twenty-eight Sprague-Dawley rats had 1.0-mm polytetrafluoroethylene (PTFE) interposition grafts placed in their femoral artery that supplied a 3.0 X 3.0 cm epigastric pedicle flap. The model is the first to evaluate 1.0-mm PTFE under rigorous, clinically simulating conditions. Anastomoses employed a new, continuous telescoping suture technique. Grafts were selected for histological and electron microscopic evaluation, which confirmed the development of a cellular neointimal lining. Viability of the flap model had a 90% correlation with graft patency. Overall graft patency was 50%. Patency was documented in some specimens harvested at 200 days. The flap model is a good indicator of graft patency. PTFE grafts of 1.0-mm internal diameter are not yet equivalent to autologous veins. Future refinements, particularly aseptic technique, are expected to result in even higher patency rates.
28只Sprague-Dawley大鼠的股动脉中植入了1.0毫米的聚四氟乙烯（PTFE）血管移植片，该血管为一个3.0×3.0厘米的腹壁带蒂皮瓣供血。该模型是首个在严格的临床模拟条件下评估1.0毫米PTFE的模型。吻合采用了一种新的连续套叠缝合技术。选取移植片进行组织学和电子显微镜评估，结果证实形成了细胞性新生内膜内衬。皮瓣模型的存活与移植片通畅率有90%的相关性。移植片总体通畅率为50%。在200天时采集的一些标本中记录到了通畅情况。皮瓣模型是移植片通畅的良好指标。内径1.0毫米的PTFE移植片尚未等同于自体静脉。预计未来的改进，特别是无菌技术，将带来更高的通畅率。
