Chen Michelle A, Chen Edith, Gallivan Shanti U, Brody Elizabeth J, Passarelli Veronica, Miller Gregory E
From the Institute of Policy Research, Northwestern University (M. Chen, E. Chen, Gallivan, Brody, Passarelli, Miller), Evanston, Illinois; and Saint Louis University School of Medicine (Brody), St. Louis, Missouri.
Psychosom Med. 2024 Oct 1;86(8):660-669. doi: 10.1097/PSY.0000000000001332. Epub 2024 Jul 4.
Childhood socioeconomic disadvantage is associated with a host of adverse health outcomes across the lifespan. However, there is increasing interest in identifying factors that may promote resilience to disadvantage's effects on health. One promising candidate in this regard is a sense of neighborhood belonging, which could offset health risks by providing a sense of connection to others, as well as a sense of belonging to a community larger than oneself.
In a sample of 245 adolescents (age: mean [standard deviation] = 15.98 [0.54] years; sex: 64.1% female; race: 41.6% White, 37.6% Black/African American, 9.8% Other; ethnicity: 68.6% non-Hispanic), we examined neighborhood belonging as a moderator of the relationship between socioeconomic disadvantage (measured on a 0- to 5-point scale, mean [standard deviation] = 1.21 [1.36]) and low-grade inflammation (measured via a composite of circulating inflammatory biomarkers including IL-6, IL-8, IL-10, TNF-α, CRP, and suPAR). Covariates included age, sex, race/ethnicity, and pubertal status.
Neighborhood belonging buffered the relationship between socioeconomic disadvantage and low-grade inflammation, a key mechanistic pathway to multiple chronic diseases. Specifically, there was a positive relationship between socioeconomic disadvantage and low-grade inflammation among individuals with low neighborhood belonging, but not among individuals with high neighborhood belonging.
These findings suggest that neighborhood belonging is one type of social connection factor that can mitigate the relationship between socioeconomic disadvantage and low-grade inflammation in youth.
儿童期的社会经济劣势与一生中一系列不良健康后果相关。然而，人们越来越有兴趣找出可能促进对劣势对健康影响的恢复力的因素。在这方面，一个有前景的候选因素是邻里归属感，它可以通过提供与他人的联系感以及对大于自身的社区的归属感来抵消健康风险。
在245名青少年样本中（年龄：平均[标准差]=15.98[0.54]岁；性别：64.1%为女性；种族：41.6%为白人，37.6%为黑人/非裔美国人，9.8%为其他；族裔：68.6%为非西班牙裔），我们考察了邻里归属感作为社会经济劣势（以0至5分制衡量，平均[标准差]=1.21[1.36]）与低度炎症（通过包括IL-6、IL-8、IL-10、TNF-α、CRP和suPAR在内的循环炎症生物标志物综合指标测量）之间关系的调节因素。协变量包括年龄、性别、种族/族裔和青春期状态。
邻里归属感缓冲了社会经济劣势与低度炎症之间的关系，低度炎症是多种慢性疾病的关键机制途径。具体而言，在邻里归属感低的个体中，社会经济劣势与低度炎症之间存在正相关，但在邻里归属感高的个体中不存在。
这些发现表明，邻里归属感是一种社会联系因素，可以减轻青少年社会经济劣势与低度炎症之间的关系。
