Department of Nursing and Physiotherapy, Universidad de Salamanca, Avd. Donantes de Sangre s/n, 37007, Salamanca, Spain.
IBSAL) and Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca, Salamanca, Spain.
Eur J Pediatr. 2024 Oct;183(10):4169-4178. doi: 10.1007/s00431-024-05712-2. Epub 2024 Aug 7.
Preterm birth represents a public health problem, with prematurity being the leading cause of infant mortality. An objective brain maturation and oxygenation measurement are necessary. The objective has been To test the feasibility of EEG and NIRS combination in the assessment of physiological brain maturation and oxygenation in preterm and non-preterm babies. A systematic review in Pubmed, Web of Science, MEDLINE, Cochrane, Dialnet, CINAHL, Scopus, Lilacs and PEDro databases until December 2022 was developed. 598 registers were found, finally 5 of them reached the inclusion criteria. Two independent reviewers analyzed data and a third reviewer were available for discrepancies. All articles combined EEG and NIRS to assess brain oxygenation and maturation in healthy new-born babies. There is an agreement on the electrode's placement for EEG at P3 and P4; besides, these regions have been shown to be a development predictive area, as well as the frontoparietal region for the NIRS region and comparison between regions. There is little evidence about the physiological brain electrical activity and oxygenation without stimuli.Conclusion: EEG and NIRS have been useful to assess brain electrical activity and oxygenation in preterm and non-preterm. The combined measurement of these instruments could be essential in neurological disorders diagnosis or their sequels. Unfortunately, the heterogeneity of the results found prevents a consensus on which variables are the most appropriate for the assessment of this population. What is Known • Brain assessment could help clinicians to prevent sequels. • There is an agreement for EEG electrodes placement at P3 and P4 region. What is New • EEG and NIRS assessment are effective measurements for preterm babies. • P3 and P4 regions have shown to be a predictive area of development, as well as the frontoparietal region for NIRS assessment.
早产是一个公共卫生问题，早产儿是婴儿死亡的主要原因。客观的大脑成熟度和氧合测量是必要的。目的是测试 EEG 和 NIRS 结合在评估早产儿和非早产儿生理脑成熟度和氧合中的可行性。在 Pubmed、Web of Science、MEDLINE、Cochrane、Dialnet、CINAHL、Scopus、Lilacs 和 PEDro 数据库中进行了系统综述，检索时间截至 2022 年 12 月。共发现 598 个登记处，最终有 5 个符合纳入标准。两名独立的评审员分析了数据，第三名评审员可处理意见分歧。所有文章都将 EEG 和 NIRS 结合起来评估健康新生儿的大脑氧合和成熟度。在 EEG 电极的放置方面，P3 和 P4 区域有共识；此外，这些区域已被证明是一个具有预测性的发育区域，NIRS 区域的前额顶区域以及区域之间的比较也是如此。关于无刺激时大脑电生理活动和氧合的证据很少。结论：EEG 和 NIRS 可用于评估早产儿和非早产儿的大脑电活动和氧合。这些仪器的联合测量对于神经障碍的诊断或其后续诊断可能至关重要。不幸的是，发现的结果存在很大的异质性，无法就哪些变量最适合评估这一人群达成共识。已知的：脑评估可以帮助临床医生预防后遗症。有共识认为 EEG 电极应放置在 P3 和 P4 区域。新的：EEG 和 NIRS 评估是早产儿的有效测量方法。P3 和 P4 区域已被证明是发育的预测区域，NIRS 评估的前额顶区域也是如此。
